LDL Cholesterol and the Development of Stroke Subtypes and Coronary Heart Disease in a General Japanese Population The Hisayama Study
LDL Cholesterol and the Development of Stroke Subtypes and Coronary Heart Disease in a General Japanese Population The Hisayama Study
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DOI：
10.1161/strokeaha.108.529537
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发表时间：
2009-02-01
期刊：
影响因子：
8.3
通讯作者：
Kiyohara, Yutaka
中科院分区：
文献类型：
--
作者：
Imamura, Tsuyoshi;Doi, Yasufumi;Kiyohara, Yutaka
背景和目的-虽然血清低密度脂蛋白胆固醇水平和冠心病（CHD）之间的关系已经很好地建立，但其与中风亚型的关系还不太清楚。方法-在一个日本社区，对2351名年龄≥ 40岁的居民进行了19年的随访。而年龄和性别校正的CHD发病率随LDL胆固醇水平的升高而显著增加（P趋势
Background and Purpose-Although the relation between serum LDL cholesterol level and coronary heart disease (CHD) is well established, its relation with stroke subtypes is less clear.Methods-A total of 2351 inhabitants age >= 40 years in a Japanese community were followed up for 19 years.Results-During follow-up, 271 subjects developed stroke and 144 developed CHD. Whereas the age- and sex-adjusted incidences of CHD significantly increased with increasing LDL cholesterol levels (P for trend