The role of tumour stroma in colorectal cancer invasion and metastasis.
The role of tumour stroma in colorectal cancer invasion and metastasis.
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DOI：
10.3390/cancers3022160
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发表时间：
2011-04-26
期刊：
影响因子：
5.2
通讯作者：
Thomas G
中科院分区：
文献类型：
--
作者：
Conti J;Thomas G
结直肠癌（CRC）是西方社会死亡的主要原因，5年生存率约为50%。转移到肝脏和肺部是死亡的主要原因，发生在高达25%的患者在介绍。尽管用于治疗转移的可用技术取得了进展，但大多数患者仍然无法治愈，并且现有的辅助疗法如化疗仅具有有限的有效性。了解转移过程的分子机制可能使我们能够识别那些复发风险最大的肿瘤，并发现新的肿瘤靶点以防止疾病进展。现在很明显，肿瘤间质在促进肿瘤进展中起着重要作用。一个明显的促结缔组织增生反应与免疫反应降低有关，并且已经被证明是CRC和癌症复发的一个独立的不良预后指标。确定这种基质反应的原因和影响将进一步加深我们对肿瘤细胞/基质相互作用的理解，并将帮助我们确定CRC患者的预后指标。这不仅使我们能够更有效地靶向我们现有的治疗方法，我们还旨在为CRC的治疗确定新的和更具体的治疗靶点，这将增加我们目前的治疗选择。
Colorectal cancer (CRC) is a major cause of mortality in western society with a 5-year survival of approximately 50%. Metastasis to the liver and lungs is the principal cause of death and occurs in up to 25% of patients at presentation. Despite advances in available techniques for treating metastases, the majority of patients remain incurable and existing adjuvant therapies such as chemotherapy are only of limited effectiveness. Understanding the molecular mechanisms underlying the metastatic process may allow us to identify those at greatest risk of recurrence and discover new tumour targets to prevent disease progression. It is now apparent that tumour stroma plays an important role in promoting tumour progression. A pronounced desmoplastic reaction was associated with a reduced immune response and has been shown to be an independent poor prognostic indicator in CRC and cancer recurrence. Determining the cause(s) and effect(s) of this stromal response will further our understanding of tumour cell/stromal interactions, and will help us identify prognostic indicators for patients with CRC. This will not only allow us to target our existing treatments more effectively, we also aim to identify novel and more specific therapeutic targets for the treatment of CRC which will add to our current therapeutic options.