The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
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DOI：
10.1097/mpa.0000000000001037
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发表时间：
2018
期刊：
影响因子：
2.9
通讯作者：
Powers AC
中科院分区：
文献类型：
--
作者：
Abbruzzese JL;Andersen DK;Borrebaeck CAK;Chari ST;Costello E;Cruz-Monserrate Z;Eibl G;Engleman EG;Fisher WE;Habtezion A;Kim SK;Korc M;Logsdon C;Lyssiotis CA;Pandol SJ;Rustgi A;Wolfe BM;Zheng L;Powers AC
2017年10月12日，美国国家糖尿病与消化和肾脏疾病研究所举办了一场名为《胰腺癌与糖尿病、肥胖和炎症的关系：研究差距和机遇》的研讨会。研讨会的目的是探讨与糖尿病相关的胰腺导管腺癌(PDAC)风险增加的关系和可能的机制，细胞内能量代谢改变在PDAC中的作用，PDAC导致糖尿病的机制和生物标志物，PDAC与肥胖相关的PDAC风险增加的机制，以及炎症事件和介质在PDAC发展中的作用。研讨会教师回顾了这些领域的当前知识状况，并为未来的研究工作提出了建议。需要进一步的知识来阐明高胰岛素血症、高血糖、脂肪因子以及急性和慢性炎症事件在PDAC发生中的作用的基本机制。
A workshop on “The Interface of Pancreatic Cancer with Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities” was held by the National Institute of Diabetes and Digestive and Kidney Diseases on October 12, 2017. The purpose of the workshop was to explore the relationship and possible mechanisms of the increased risk of pancreatic ductal adenocarcinoma (PDAC) related to diabetes, the role of altered intracellular energy metabolism in PDAC, the mechanisms and biomarkers of diabetes caused by PDAC, the mechanisms of the increased risk of PDAC associated with obesity, and the role of inflammatory events and mediators as contributing causes of the development of PDAC. Workshop faculty reviewed the state of the current knowledge in these areas and made recommendations for future research efforts. Further knowledge is needed to elucidate the basic mechanisms contributing to the role of hyperinsulinemia, hyperglycemia, adipokines, and acute and chronic inflammatory events on the development of PDAC.