PROLACTIN AND ADRENAL ANDROGEN SECRETION
PROLACTIN AND ADRENAL ANDROGEN SECRETION
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催乳素和肾上腺雄激素分泌
DOI：
10.1111/j.1365-2265.1978.tb02772.x
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发表时间：
1977
影响因子：
3.2
通讯作者：
S. Andò
中科院分区：
文献类型：
--
作者：
A. Vermeulen;S. Andò
本研究的目的是研究催乳素在肾上腺分泌脱氢表雄酮（DHA）及其硫酸盐（DHA-S）中的作用。因此，在各种生理和病理条件下，在不同组的受试者中测定催乳素和DHA-S水平。在泌乳素瘤患者中，或在高泌乳素血症患者中，血浆DHA-S浓度升高，DHA-S血液生成率大大增加。ACTH刺激不会影响正常人的DHA‐S浓度，但会导致泌乳素瘤患者的DHA浓度显著增加;正常受试者和泌乳素瘤患者的DHA浓度增加相似。溴隐亭治疗催乳素血症患者使催乳素和DHA‐S浓度正常化。与长期治疗相比，TRH刺激或短期舒必利给药导致正常受试者催乳素急性升高并不影响DHA‐S水平。在怀孕期间，尽管催乳素浓度较高，但DHA-S浓度低于月经周期。在泌乳素瘤患者中，给予皮质醇替代糖皮质激素，尽管泌乳素浓度持续高，但DHA‐S浓度较低（正常）。得出的结论是，只有催乳素的长期升高才能诱导肾上腺皮质分泌DHA-S增加，而正常的ACTH分泌是这种作用的先决条件。怀孕期间没有升高的DHA-S浓度可能是由于代谢速度快，因为DHA-S的产生速度增加。然而，催乳素和ACTH在肾上腺皮质相互作用的密切机制仍然未知。
The aim of this study was to investigate the role of prolactin in the secretion by the adrenal of dehydroepiandrosterone (DHA) and its sulphate (DHA‐S). Therefore prolactin and DHA‐S levels were determined in different groups of subjects under various physiological and pathological conditions. In patients with prolactinomas, or with pharmacologically induced hyperprolactinaemia, plasma DHA‐S and, to lesser extend, DHA concentrations were elevated, and the DHA‐S blood production rate greatly increased. ACTH stimulation which did not influence DHA‐S concentrations in normals, caused a significant increase in patients with prolactinomas; the increase in DHA concentrations was similar in normal subjects and in prolactinoma patients. Bromocriptine treatment of prolactinaemia patients normalized both prolactin and DHA‐S concentrations. Acute elevation of prolactin in normal subjects by TRH stimulation or by short term administration of sulpiride, in contrast to long term treatment, did not influence DHA‐S levels. During pregnancy, notwithstanding high prolactin concentrations, DHA‐S concentrations were lower than during the menstrual cycle. In patients with prolactinomas, given glucocorticoid replacement with cortisol, DHA‐S concentrations were low (normal) notwithstanding persistently high prolactin concentrations. It is concluded that only prolonged elevation of prolactin induces increased DHA‐S secretion by the adrenal cortex and that normal ACTH secretion is a prerequisite for this effect. The absence of elevated DHA‐S concentrations in pregnancy might be explained by the rapid rate of metabolism, as the DHA‐S production rate is increased. The intimate mechanism of prolactin and ACTH interaction at the adrenal cortex remains however unknown.