Associations between paternal urinary phthalate metabolite concentrations and reproductive outcomes among couples seeking fertility treatment
Associations between paternal urinary phthalate metabolite concentrations and reproductive outcomes among couples seeking fertility treatment
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DOI：
10.1016/j.reprotox.2015.09.007
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发表时间：
2015-12-01
影响因子：
3.3
通讯作者：
Hauser, R.
中科院分区：
文献类型：
--
作者：
Dodge, L. E.;Williams, P. L.;Hauser, R.
简介：有限的证据表明，男性暴露于无处不在的环境邻苯二甲酸酯可能会导致不良的生殖结果之间的女性partners.Methods：这项分析包括男性女性夫妇进行体外受精（IVF）和/或宫腔内人工授精（IUI）。我们评估了几何平均值的父亲特定重力调整的尿邻苯二甲酸酯浓度之前，女性合作伙伴的周期和受精，胚胎质量，植入，活产广义线性mixed models.Results：二百十八对夫妇进行了211 IVF和195 IUI周期之间的关联。在父亲尿邻苯二甲酸单-3-羧丙酯（MCPP; P=0.01）和邻苯二甲酸单（羧辛酯）（MCOP; P = 0.01）之间观察到趋势，并降低了着床几率。MCPP和MCOP也与IVF后活产率降低相关（分别为P = 0.01和P = 0.04），邻苯二甲酸单丁酯高于第一四分位数与IUI后活产率降低显著相关（P= 0.04）。然而，大多数尿邻苯二甲酸酯代谢产物与这些生殖outcome.Conclusion：选择邻苯二甲酸酯与植入和活产的几率降低。(C)2015 Elsevier Inc. All rights reserved.
Introduction: Limited evidence suggests that male exposure to ubiquitous environmental phthalates may result in poor reproductive outcomes among female partners.Methods: This analysis included male female couples undergoing in vitro fertilization (IVF) and/or intrauterine insemination (IUI). We evaluated associations between the geometric mean of paternal specific gravity-adjusted urinary phthalate concentrations prior to the female partners' cycle and fertilization, embryo quality, implantation, and live birth using generalized linear mixed models.Results: Two-hundred eighteen couples underwent 211 IVF and 195 lUI cycles. Trends were observed between paternal urinary mono-3-carboxypropyl phthalate (MCPP; P=0.01) and mono(carboxyoctyl) phthalate (MCOP; P = 0.01) and decreased odds of implantation. MCPP and MCOP were also associated with decreased odds of live birth following IVF (P = 0.01 and P = 0.04, respectively), and monobutyl phthalate above the first quartile was significantly associated with decreased odds of live birth following IUI (P= 0.04). However, most urinary phthalate metabolites were not associated with these reproductive outcomes.Conclusion: Selected phthalates were associated with decreased odds of implantation and live birth. (C) 2015 Elsevier Inc. All rights reserved.