Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation.
Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation.
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DOI：
10.3389/fimmu.2018.00804
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发表时间：
2018
影响因子：
7.3
通讯作者：
Sancho D
中科院分区：
文献类型：
--
作者：
Del Fresno C;Iborra S;Saz-Leal P;Martínez-López M;Sancho D
髓样C型凝集素受体（CLRs）是与其他模式识别受体（PRRs）协同工作的自我和非自我的重要传感器。以前已基于其信号传导基序将CLR分类为活化或抑制受体。然而，配体结合过程的特定特征可能导致通过单个基序的不同信号传导，从而导致非经典途径的触发。此外，CCLs配体经常暴露于同时结合不同的CLR和其他PRR的复杂结构中，这导致异源信号传导在不同受体之间的整合。在此，我们将审查如何通过骨髓CLRs和异源受体的串扰的传感是由许多因素影响其信号传导，并导致免疫和炎症的不同结果调制。在由不同的CLR配体伴侣引发的灵活反应中找到共同特征将有助于利用免疫和炎症中的免疫功能。
Myeloid C-type lectin receptors (CLRs) are important sensors of self and non-self that work in concert with other pattern recognition receptors (PRRs). CLRs have been previously classified based on their signaling motifs as activating or inhibitory receptors. However, specific features of the ligand binding process may result in distinct signaling through a single motif, resulting in the triggering of non-canonical pathways. In addition, CLR ligands are frequently exposed in complex structures that simultaneously bind different CLRs and other PRRs, which lead to integration of heterologous signaling among diverse receptors. Herein, we will review how sensing by myeloid CLRs and crosstalk with heterologous receptors is modulated by many factors affecting their signaling and resulting in differential outcomes for immunity and inflammation. Finding common features among those flexible responses initiated by diverse CLR-ligand partners will help to harness CLR function in immunity and inflammation.