Science Signaling Podcast for 2 August 2016: Patient-specific protein complexes.
Science Signaling Podcast for 2 August 2016: Patient-specific protein complexes.
复制标题
2016 年 8 月 2 日科学信号播客：患者特异性蛋白质复合物。
DOI：
10.1126/scisignal.aah5912
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发表时间：
2016
影响因子：
7.3
通讯作者：
VanHook,AnnalisaM
中科院分区：
文献类型：
--
作者：
Schrum,AdamG;Neier,StevenC;VanHook,AnnalisaM
这期播客采访了Adam Schrum和Steven Neier，他们发表在2016年8月2日的science Signaling杂志上的一篇研究文章的作者，关于一种识别患者组织样本中蛋白质-蛋白质相互作用的方法。作者使用这种方法比较了来自健康皮肤的T细胞中T细胞受体下游的信号复合物与来自自身免疫性疾病斑秃患者皮肤的T细胞中的信号复合物。该研究揭示了对照组和患者组T细胞中某些蛋白质复合物相对丰度的差异。这项技术可以作为一种诊断工具，通过分子表型对患者进行分层，并预测可能对每位患者最有效的治疗策略。听播客
This Podcast features an interview with Adam Schrum and Steven Neier, authors of a Research Article that appears in the 2 August 2016 issue ofScience Signaling, about a method for identifying protein-protein interactions in patient tissue samples. The authors used this method to compare signaling complexes downstream of the T cell receptor in T cells from healthy skin with those in T cells from the skin of patients with the autoimmune disease alopecia areata. The study revealed differences in the relative abundance of some protein complexes between T cells from the control and patient groups. This technique could be adapted for use as a diagnostic tool to stratify patients by molecular phenotype and predict the therapeutic strategy that is likely to work best for each patient.Listen to Podcast