Valence-specific regulation effects in a working memory task with emotional context
Valence-specific regulation effects in a working memory task with emotional context
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DOI：
10.1016/j.neuroimage.2007.05.006
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发表时间：
2007-08-15
期刊：
影响因子：
5.7
通讯作者：
Walter, Henrik
中科院分区：
文献类型：
--
作者：
Erk, Susanne;Kleczar, Anna;Walter, Henrik
最近已经显示出情绪背景对情景记忆的调节作用。我们感兴趣的是工作记忆是否同样容易受到情绪背景的影响，或者工作记忆是否有助于分散情绪，即下调情绪反应以维持先前的意图。我们通过在具有两种负载条件的 Sternberg 项目识别任务中调节维护过程的情感背景，测试了主动维护信息期间情感刺激的效果。行为数据显示，在情绪背景下，工作记忆表现没有受到损害。事实上，在高负荷期间，与中性环境相比，情绪方面的行为表现更好。此外，情绪环境对工作记忆相关的大脑激活没有干扰作用。相反，我们发现了价态特异性调节效应：高认知努力与情绪处理区域（即杏仁核和腹侧纹状体）的活动减少有关。这种效应是由不同的前额叶区域介导的，即左下 PFC 介导负价，左上 PFC 介导正价。此外，我们的结果揭示了右侧背外侧前额叶皮层中情绪和认知的整合效应，随着任务复杂性的增加，招募也随之增加。这里提出的结果对于理解调节机制和以情绪干扰敏感性增加为特征的疾病具有相关性。 (c) 2007 Elsevier Inc. 保留所有权利。
The modulatory effects of emotional context on episodic memory have been shown recently. We were interested whether working memory is similarly susceptible to emotional context or whether working memory helps to distract from emotion, i.e. serves to downregulate emotional reactions in order to sustain the prior intention. We tested the effects of emotional stimulation during active maintenance of information by modulating the emotional context of maintenance processes in a Sternberg item recognition task with two load conditions. Behavioral data revealed no impairment of working memory performance during emotional context. Actually, behavioral performance was better for emotional compared to neutral context during high load. Furthermore, emotional context had no interference effect on working memoryrelated brain activation. Instead, we found a valence-specific regulation effect: High cognitive effort was associated with reduced activity in emotion processing regions, i.e. the amygdala and ventral striatum. This effect was mediated by different prefrontal regions, i.e. by left inferior PFC for negative and left superior PFC for positive valence. Furthermore, our results reveal an integration effect of emotion and cognition in right dorsolateral prefrontat cortex showing increased recruitment with increasing complexity of the task. The results presented here are of relevance for the understanding of regulatory mechanisms and diseases characterized by increased susceptibility to emotional distraction. (c) 2007 Elsevier Inc. All rights reserved.