Platelet Distribution Width and Mean Platelet Volume in Children With Pulmonary Arterial Hypertension Secondary to Congenital Heart Disease With Left-to-Right Shunt: New Indices of Severity?
Platelet Distribution Width and Mean Platelet Volume in Children With Pulmonary Arterial Hypertension Secondary to Congenital Heart Disease With Left-to-Right Shunt: New Indices of Severity?
复制标题
DOI：
10.1007/s00246-012-0600-5
复制
发表时间：
2013-04-01
影响因子：
1.6
通讯作者：
Oran, Bulent
中科院分区：
文献类型：
--
作者：
Arslan, Derya;Cimen, Derya;Oran, Bulent
大多数先天性心脏病(CHD)患者，特别是那些有相关的体肺分流的患者，如果不治疗，将经历肺动脉高压(PAH)的发展。先前的研究表明，PAH患者存在血小板活化。因此，本研究旨在探讨PAH患者的血小板指数，包括血小板分布宽度(PDW)和平均血小板体积(MPV)。这项研究于2010年7月至2012年1月在塞尔库克大学医学院的儿科心脏病科进行。患者的临床和实验室数据是从医院记录中回顾获得的。这项研究招募了57名患有CHD的儿童(都是从左向右分流的)。根据有无PAH对接受诊断性心导管术的患者进行分析。第1组为冠心病合并PAH，第2组为冠心病不伴PAH。与组2患者相比，组1患者的PDW显著降低(p<；0.0001)。同样，第1组的MPV也有显著差异(P<；0.0001)。统计学上，第1组和第2组在血小板计数方面没有差异(p=0.3)。左向右分流的CHD继发肺动脉高压患者的PDW和MPV较低。
The majority of patients with congenital heart disease (CHD), particularly those with relevant systemic-to-pulmonary shunts, if left untreated, will experience the development of pulmonary arterial hypertension (PAH). Previous studies have shown that platelet activation occurs in patients with PAH. In response, this study aimed to investigate the platelet indices, including platelet distribution width (PDW) and mean platelet volume (MPV), in patients with PAH. The study was conducted in the pediatrics cardiology unit of Selcuk University Medical Faculty between July 2010 and January 2012. The patients' clinical and laboratory data were obtained retrospectively from hospital recordings. The study enrolled 57 children with CHD (all with left-to-right shunting). The patients who had undergone diagnostic cardiac catheterization were analyzed according to the presence or absence of PAH. Group 1 had CHD with PAH, and group 2 had CHD without PAH. Compared with the group 2 patients, a significant decrease in PDW (p < 0.0001) was noted in the group 1 patients (with PAH). Likewise, a significant difference was found in the MPV of group 1 (p < 0.0001). Statistically, groups 1 and 2 did not differ in terms of platelet count (p = 0.3). Patients who had pulmonary hypertension secondary to CHD with left-to-right shunting exhibited a lower PDW and MPV.