Investigation of Thermal Effects of Radiofrequency Ablation Mediated with Iron Oxide Nanoparticles Dispersed in Agarose and Chitosan Solvents
Investigation of Thermal Effects of Radiofrequency Ablation Mediated with Iron Oxide Nanoparticles Dispersed in Agarose and Chitosan Solvents
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DOI：
10.3390/app11052437
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发表时间：
2021-03-01
影响因子：
2.7
通讯作者：
Tosi, Daniele
中科院分区：
文献类型：
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作者：
Ashikbayeva, Zhannat;Aitkulov, Arman;Tosi, Daniele
热消融（TA）被认为是手术治疗肿瘤的替代疗法。然而，基于TA的治疗需要先进的方法，以防止对肿瘤周围的健康组织造成损伤，并选择性地靶向所需区域。纳米颗粒被认为是生物医学中满足这些要求的有前途的工具。本研究旨在分析纳米氧化铁对猪肝射频消融治疗过程中温升的影响。此外，本研究旨在实验评估两种溶剂，如琼脂糖和壳聚糖的温度变化的影响，当磁性纳米粒子分散在其中。采用溶剂热法合成了氧化铁纳米粒子，并通过外加磁场的作用展示了其磁性。为了增加局部热，对于每种浓度和溶剂，以10个重复测试平均尺寸为20 nm的超顺磁性纳米颗粒（氧化铁磁性纳米颗粒（IONP））和浓度为1至10 mg/mL的MNP，步长为1 mg/mL。此外，检查干肝和0 mg/mL浓度的温度变化，以进行校准和参考。作为一个传感系统，先进的16-FBG光纤传感器连接到一个温度传感器，允许温度变化进行精确监测，在真实的时间。通过分散在琼脂糖溶剂中的浓度为5 mg/mL的氧化铁纳米颗粒记录到约142摄氏度的最高温度。
Thermal ablation (TA) is known as an alternative therapy to surgery to treat tumors. However, TA-based therapy requires advanced approaches in order to prevent causing damage to healthy tissue around the tumor and selectively target the desired area. Nanoparticles are considered as a promising tool in biomedicine to fulfill these requirements. This study was carried out in order to analyze the effect of iron oxide nanoparticles on the temperature increment during radiofrequency ablation therapy of porcine liver. In addition, this research aimed to experimentally evaluate the impact of two solvents such as agarose and chitosan on the temperature change, when magnetic nanoparticles were dispersed in them. The iron oxide nanoparticles were synthesized by the solvothermal method demonstrating the magnetic properties by acting to the external magnetic field. To increase the local heat superparamagnetic nanoparticles (iron oxide magnetic nanoparticle (IONPs)) of the average size of 20 nm in size and the concentrations from 1 to 10 mg/mL of MNPs with a step size of 1 mg/mL were tested in 10 replicates for each concentration and solvent. Moreover, the temperature changes for dry liver, and 0 mg/mL concentration was checked for calibration and reference purposes. As a sensing system, advanced 16-FBG optical fiber sensors connected to an interrogator were employed allowing the temperature change to be monitored accurately in real time. A maximum temperature of about 142 degrees C was recorded by a 5 mg/mL concentration of iron oxide nanoparticles dispersed in the agarose solvent.