Tonic GABAergic and cholinergic influences on pain control and cardiovascular control neurones in nucleus paragigantocellularis lateralis in the rat
Tonic GABAergic and cholinergic influences on pain control and cardiovascular control neurones in nucleus paragigantocellularis lateralis in the rat
复制标题
强效 GABA 能和胆碱能对大鼠外侧巨细胞核疼痛控制和心血管控制神经元的影响
DOI：
10.1016/0304-3959(87)90168-0
复制
发表时间：
1987
期刊：
影响因子：
7.4
通讯作者：
T. Lovick
中科院分区：
文献类型：
--
作者：
T. Lovick
在用阿法沙龙/阿法多龙（Saffan）麻醉的大鼠中，将GABA拮抗剂荷包牡丹碱双侧微量注射到面神经核尾极腹内侧的旁巨细胞外侧核（PGL）的限制区域中，引起对有害热的甩尾反应的潜伏期增加。镇痛总是伴随着平均动脉血压的上升，但心血管和抗伤害性变化的时间过程是不同的。静脉注射乙啶（7 mg/kg）可阻断加压反应，但对镇痛的幅度和时间过程无影响。相反，在PGL中微量注射毒扁豆碱产生按压反应，但不改变甩尾反应的潜伏期。
: In rats anaesthetised with alphaxalone/alphadolone (Saffan), bilateral microinjections of the GABA antagonist, bicuculline, into a restricted region of nucleus paragigantocellularis lateralis (PGL), ventromedial to the caudal pole of the facial nucleus, produced an increase in the latency of the tail flick response to noxious heat. The analgesia was always accompanied by a rise in mean arterial blood pressure but the time course of the cardiovascular and antinociceptive changes was different. Guanethidine (7 mg/kg iv) blocked the presser response but had no effect on the magnitude or time course of the analgesia. In contrast, microinjection of physostigmine into PGL produced a presser response but no change in the latency of the tail flick response.
延髓头端腹外侧胆碱能机制对心血管的控制。
DOI：
--
发表时间：
1984
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Willette,RN;Punnen,S;Krieger,AJ;Sapru,HN
通讯作者：
Sapru,HN