Cardiovascular Autonomic Neuropathy and Early Atherosclerosis in Adolescent Type 1 Diabetic Patient.
Cardiovascular Autonomic Neuropathy and Early Atherosclerosis in Adolescent Type 1 Diabetic Patient.
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DOI：
10.3889/oamjms.2015.131
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发表时间：
2015-12-15
影响因子：
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通讯作者：
Bohy Ael M
中科院分区：
文献类型：
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作者：
Dayem SM;Battah AA;Bohy Ael M
目的探讨1型糖尿病患者心血管自主神经病变（CAN）与冠状动脉钙化的关系。这是一项横断面研究，包括62名糖尿病患者和30名对照。对所有患者和对照组进行临床、实验室评估和24小时动态霍尔特，仅对所有患者进行多层螺旋CT冠状动脉钙化（CAC）评分。统计分析采用t检验、Mann Whitney U检验和多元逐步回归。8.1%的患者CAC评分为阳性。糖尿病患者心率变异性（HRV）显著降低。CAC评分阳性的糖尿病患者HRV各参数均较正常对照组降低，但差异无统计学意义。微量白蛋白尿患者HRV显著降低。糖尿病患者心率变异性与年龄、病程、HbA1、Qtc有显著相关性。青少年1型糖尿病患者心律失常和早期动脉粥样硬化的比例较高。CAN与早期动脉粥样硬化有关。心脏自主神经病变与年龄较大、病程较长、血糖控制不良和微量白蛋白尿有关。
To evaluate cardiovascular autonomic neuropathy (CAN) in type 1 Diabetics and to detect its relation to coronary artery calcification. It is a cross sectional study included 62 diabetics and 30 controls. Clinical, laboratory assessment and 24 Hr holter were done for all patients and controls and coronary artery calcium (CAC) scoring by multisclice CT was done for all patients only. T-test, Mann Whitney U test, and stepwise multiple regression were used for statistical analyses. CAC score was positive in 8.1 % of patients. Heart rate variability (HRV) was significantly lower in diabetics. All parameters of HRV were insignificantly lower in diabetics with positive CAC score. Patients with microalbuminuria had a significantly lower HRV. HRV had a significant correlation with age of patients, duration of disease, HbA1, and Qtc in diabetics. Percentage of arrhythmia and early atherosclerosis is high in adolescent type 1 diabetic patients. CAN is associated with early atherosclerosis. Cardiac autonomic neuropathy is associated with older age, longer duration, and poor glycemic control and microalbuminuria.