NEUROPHYSIOLOGICAL ANALYSIS OF BRAIN-STIMULATION REWARD IN THE MONKEY
NEUROPHYSIOLOGICAL ANALYSIS OF BRAIN-STIMULATION REWARD IN THE MONKEY
复制标题
DOI：
10.1016/0006-8993(80)91216-0
复制
发表时间：
1980-01-01
期刊：
影响因子：
2.9
通讯作者：
MORA, F
中科院分区：
文献类型：
--
作者：
ROLLS, ET;BURTON, MJ;MORA, F
在恒河猴和松鼠猴中分析了与脑刺激奖励和喂食相关的神经元活动。发现下丘脑外侧区、眶额皮质、杏仁核和延髓核等部位存在自我刺激，下丘脑外侧区的单个神经元群可从1个或多个自我刺激部位跨突触激活。眶额皮质和杏仁核中的神经元群体至少从一些自我刺激部位被激活。在猴子身上，有证据表明存在一组相互关联的自我刺激部位，其中任何一个部位的刺激都可能激活其他区域的神经元。这些部位包括外侧下丘脑、杏仁核和眶额皮质。在1个样本的764个神经元，在外侧下丘脑和无名质，从脑刺激奖励网站激活，13.6%也被激活，在喂养过程中，由视觉和/或食物的味道。只有当某些物质（例如，甜味物质（如葡萄糖）在口中的存在，取决于被品尝物质的浓度，并且与猴子的嘴部运动无关。这些神经元在猴子饥饿时对食物产生反应，而在它们吃饱时则不会。自我刺激发生在下丘脑外侧和无名质的这些神经元的区域，并被饱腹感减弱。一些大脑部位的自我刺激显然是因为饥饿动物的视觉和/或味觉激活了外侧下丘脑和无名质中的神经元而发生的;这些神经元参与了对食物奖励的反应。
Neuronal activity related to brain-stimulation reward and to feeding was analyzed in rhesus monkeys and squirrel monkeys. Self-stimulation of the lateral hypothalamus, orbitofrontal cortex, amygdala and nucleus accumbens was found. A population of single neurons in the lateral hypothalamus was trans-synaptically activated from 1 or several self-stimulation sites. Populations of neurons in the orbitofrontal cortex and amygdala were activated from at least some of the self-stimulation sites. In the monkey, there is evidence for an interconnected set of self-stimulation sites, stimulation in any one of which may activate neurons in the other regions. These sites include the lateral hypothalamus, amygdala, and orbitofrontal cortex. In 1 sample of 764 neurons in the lateral hypothalamus and substantia innominata which were activated from brain-stimulation reward sites, 13.6% were also activated during feeding, by the sight and/or taste of food. The responses of the neurons with activity associated with taste occurred only while some substances (e.g., sweet substances such as glucose) were in the mouth, depended on the concentration of the substances being tasted, and were independent of mouth movements made by the monkeys. The responses of these neurons occurred to food when the monkeys were hungry, but not when they were satiated. Self-stimulation occurred in the region of these neurons in the lateral hypothalamus and substantia innominata, and was attenuated by satiety. Self-stimulation of some brain sites apparently occurs because of activation of neurons in the lateral hypothalamus and substantia innominata activated by the sight and/or taste of food in the hungry animal; these neurons are involved in responses to food reward.