Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD study
Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD study
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DOI：
10.1007/s00776-009-1395-y
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发表时间：
2009-11-01
影响因子：
1.7
通讯作者：
Yoshimura, Noriko
中科院分区：
文献类型：
--
作者：
Oka, Hiroyuki;Akune, Toru;Yoshimura, Noriko
本研究试图确定饮食营养与日本老年人放射学膝骨性关节炎(OA)患病率的关系。从ROAD研究的基线调查中，对一个农村队列中60岁(270名男性，449名女性)的719名参与者进行了分析。前1个月的膳食营养素摄入量通过自我管理的简短饮食史问卷进行评估。采用Kellgren/Lawrence(KL)膝关节骨性关节炎诊断系统，膝关节骨关节炎患病率为70.8%。年龄、体重指数、女性与患病率呈正相关。多因素Logistic回归分析显示，在饮食因素中，只有维生素K摄入量与放射学膝关节骨性关节炎的患病率呈负相关。膝关节间隙变窄也与维生素K摄入量呈负相关。随着维生素K摄入量的增加，每四分位数膳食维生素K摄入量所对应的膝骨性关节炎的发生率也随之降低。本研究采用基于人群的队列横断面研究，支持膳食维生素K摄入量低是膝骨性骨性关节炎的危险因素的假设。维生素K可能对膝盖骨关节炎有保护作用，并可能导致疾病修正治疗。
The present study sought to identify dietary nutrients associated with the prevalence of radiographic knee osteoarthritis (OA) in the Japanese elderly of a population-based cohort of the Research on Osteoarthritis Against Disability (ROAD) study.From the baseline survey of the ROAD study, 719 participants a parts per thousand yen60 years of age (270 men, 449 women) of a rural cohort were analyzed. Dietary nutrient intakes for the previous 1 month were assessed by a self-administered brief diet history questionnaire. The radiographic severity at both knees was determined by the Kellgren/Lawrence (KL) system.The prevalence of knee OA of KL a parts per thousand yen2 was 70.8%. Age, body mass index, and female sex were positively associated with the prevalence. Among the dietary factors, only vitamin K intake was shown to be inversely associated with the prevalence of radiographic knee OA by multivariate logistic regression analysis. The presence of joint space narrowing of the knee was also inversely associated with vitamin K intake. The prevalence of radiographic knee OA for each dietary vitamin K intake quartile decreased with the increased intake.The present cross-sectional study using a population-based cohort supports the hypothesis that low dietary vitamin K intake is a risk factor for knee OA. Vitamin K may have a protective role against knee OA and might lead to a disease-modifying treatment.