LIN28: roles and regulation in development and beyond
LIN28: roles and regulation in development and beyond
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DOI：
10.1242/dev.117580
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发表时间：
2015-07-15
期刊：
影响因子：
4.6
通讯作者：
Romer-Seibert, Jennifer
中科院分区：
文献类型：
--
作者：
Tsialikas, Jennifer;Romer-Seibert, Jennifer
LIN28是一种RNA结合蛋白，最为人所知的是它通过调节microRNA let-7促进多能性。然而，最近的研究发现了LIN28的新角色，并揭示了它的功能，这表明它不仅仅是miRNA生物发生的调节因子。总之，这些发现暗示了LIN28的一个新范式--作为一个把关分子，以let-7依赖和let-7非依赖的方式调节多能性和承诺细胞谱系之间的转换。在这里，我们提供了LIN28在发育和疾病中的功能概述。
LIN28 is an RNA-binding protein that is best known for its roles in promoting pluripotency via regulation of the microRNA let-7. However, recent studies have uncovered new roles for LIN28 and have revealed how it functions, suggesting that it is more than just a regulator of miRNA biogenesis. Together, these findings imply a new paradigm for LIN28 - as a gatekeeper molecule that regulates the transition between pluripotency and committed cell lineages, in both let-7-dependent and let-7-independent manners. Here, we provide an overview of LIN28 function in development and disease.