Ir‐Catalyzed α‐Alkylation of Methyl Ketones with Primary Carbohydrate Alcohols
Ir‐Catalyzed α‐Alkylation of Methyl Ketones with Primary Carbohydrate Alcohols
复制标题
Ir 催化甲基酮与碳水化合物伯醇的 α-烷基化
DOI：
10.1002/adsc.202300124
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发表时间：
2023
影响因子：
5.4
通讯作者：
Nishimura Takahiro
中科院分区：
文献类型：
--
作者：
Tsuge Kouki;Kubota Shunnichi;Sakamoto Kana;Kitayama Kenji;Nishimura Takahiro
铱催化的甲基酮与伯碳水化合物醇的α-烷基化反应通过借氢策略进行。具有一个游离伯羟基的受保护的糖衍生物与甲基酮反应，得到α-烷基化产物或烷基化4，5-不饱和糖沿着烷氧基的消除。
Iridium‐catalyzed α‐alkylation of methyl ketones with primary carbohydrate alcohols proceeded via borrowing hydrogen strategy. Protected sugar derivatives having one free primary hydroxyl group reacted with methyl ketones to give the α‐alkylation products or alkylated 4,5‐unsaturated sugars along with the elimination of an alkoxy group.