Prevalence and clinical associations of CXCR4-using HIV-1 among treatment-naive subtype C-infected women in Botswana.
Prevalence and clinical associations of CXCR4-using HIV-1 among treatment-naive subtype C-infected women in Botswana.
复制标题
DOI：
10.1097/qai.0b013e318214fe27
复制
发表时间：
2011-05-01
期刊：
影响因子：
--
通讯作者：
Kuritzkes DR
中科院分区：
文献类型：
--
作者：
Lin NH;Smeaton LM;Giguel F;Novitsky V;Moyo S;Mitchell RM;Makhema J;Essex M;Lockman S;Kuritzkes DR
采用表型分析法测定了感染C亚型病毒且CD 4细胞计数低于200个/mm 3的未接受过治疗的女性患者的血浆样本中人类免疫缺陷病毒1型（HIV-1）辅助受体的使用情况。在148名妇女中，14.9%感染了双重/混合（DM）病毒;其余感染了R5病毒。在CD 4细胞计数最低层的妇女中，有DM病毒的比例更大（p=0.026）; ART暴露后辅助受体使用的变化并不常见。使用CXCR 4的HIV-1在C亚型感染的女性中比在B亚型队列中报告的要少，但在CD 4细胞计数最低的女性中最常见。
Human immunodeficiency virus type 1 (HIV-1) coreceptor usage was determined using a phenotypic assay in plasma samples from treatment-naive women infected with subtype C virus who had CD4 cell counts below 200 cells/mm3. Of 148 women 14.9% were infected with dual/mixed (DM) virus; the remainder had R5 virus. A greater proportion of women in the lowest CD4 cell count stratum had DM virus (p=0.026); change in coreceptor use after ART exposure was uncommon. CXCR4-using HIV-1 was less common in subtype C-infected women than reported in subtype B cohorts, but was most prevalent in women with the lowest CD4 cell counts.