High-endothelial-venule ligands for L-selectin: identification and functions.
High-endothelial-venule ligands for L-selectin: identification and functions.
复制标题
L-选择素的高内皮小静脉配体：鉴定和功能。
DOI：
10.1042/bst0250428
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发表时间：
1997
影响因子：
3.9
通讯作者：
Singer,MS
中科院分区：
文献类型：
--
作者：
Rosen,SD;Hwang,ST;Giblin,PA;Singer,MS
L-选择素，白细胞选择素，介导白细胞-内皮相互作用的许多实例[11]。最近，它还涉及剪切下的白细胞-白细胞相互作用，这可能会在初级白细胞-内皮细胞结合后增强白细胞蓄积[Z]。L-选择素首先被认为是淋巴结“归巢受体”，参与淋巴细胞与淋巴结中高内皮微静脉（HEV）的结合[3，4]。该功能的最令人信服的证实来自L-选择素缺失小鼠，其表现出非常小的淋巴结，并且几乎完全不存在淋巴细胞从血液进入外周淋巴结的短期积累[S]。
L-selectin, the leucocyte selectin, mediates many examples of leucocyte-endothelial interactions [11. Recently, it has been additionally implicated in leucocyte-leucocyte interactions under shear, which may enhance leucocyte accumulation, subsequent to primary leucocyte-endothelial binding [Z]. L-selectin was first appreciated as a lymphnode ‘homing receptor’involved in the binding of lymphocytes to high endothelial venules (HEVs) in lymph nodes [3, 4]. The most compelling confirmation of this function comes from a L-selectin null mouse, which exhibits very small lymph nodes and an almost complete absence of short-term accumulation of lymphocytes from the blood into peripheral lymph nodes [S].