Trojan peptides: the penetratin system for intracellular delivery
Trojan peptides: the penetratin system for intracellular delivery
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DOI：
10.1016/s0962-8924(97)01214-2
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发表时间：
1998-02-01
影响因子：
19
通讯作者：
Prochiantz, A
中科院分区：
文献类型：
--
作者：
Derossi, D;Chassaing, G;Prochiantz, A
活细胞对外源性大分子的内化作用为研究细胞功能提供了一个强有力的途径。了解从细胞外环境转移到细胞质和细胞核的机制也有助于开发新的治疗方法。本文总结了穿透素的意想不到的特性，一类具有转位特性的肽，能够携带亲水性化合物穿过质膜。这种独特的系统允许寡肽和寡核苷酸直接靶向细胞质和细胞核，是非细胞类型特异性和高效的，因此具有潜在的细胞生物学和临床意义的几个应用。
Internalization of exogenous macromolecules by live cells provides a powerful approach for studying cellular functions. Understanding the mechanism of transfer from the extracellular milieu to the cytoplasm and nucleus could also contribute to the development of new therapeutic approaches. This article summarizes the unexpected properties of penetratins, a class of peptides with translocating properties and capable of carrying hydrophilic compounds across the plasma membrane. This unique system allows direct targeting of oligopeptides and oligonucleotides to the cytoplasm and nucleus, is non-cell-type specific and highly efficient, and therefore has several applications of potential cell-biology and clinical interest.