EFFECT OF MELATONIN AND PINEALECTOMY ON AVOIDANCE AND EXPLORATORY ACTIVITY IN RAT
EFFECT OF MELATONIN AND PINEALECTOMY ON AVOIDANCE AND EXPLORATORY ACTIVITY IN RAT
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DOI：
10.1016/0031-9384(74)90087-0
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发表时间：
1974-01-01
影响因子：
2.9
通讯作者：
LISSAK, K
中科院分区：
文献类型：
--
作者：
KOVACS, GL;GAJARI, I;LISSAK, K
每日50μg/大鼠剂量的褪黑激素促进主动回避反射的消失，并降低消失过程中的间期活动。然而，它对习得过程中的学习和试间活动没有影响。松果体切除术对于获得、消退和间期活动无效。在两个不同的实验情况下，连续两天给予褪黑激素（100微克/大鼠）促进了缺水动物的被动回避行为。 50 μg 褪黑激素或松果体切除术对被动回避行为没有影响。褪黑激素和松果体切除术对饮水量或探索活动均没有任何影响。
Melatonin in a daily dose of 50 μg/rat facilitated the extinction of active avoidance reflex and decreased the intertrial activity during extinction. However, it had no effect on learning and intertrial activity during acquisition. Pinealectomy was ineffective on acquisition, extinction and intertrial activity. Melatonin (100 μg/rat) given in 2 consecutive days facilitated the passive avoidance behavior in water deprived animals in two different experimental situations. Fifty μg of melatonin or pinealectomy was without effect on passive avoidance behavior. Neither melatonin nor pinealectomy had any influence on water intake or on exploratory activity.