Relationship between blood plasma prostaglandin E2 and liver and lung metastases in colorectal cancer
Relationship between blood plasma prostaglandin E2 and liver and lung metastases in colorectal cancer
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血浆前列腺素E2与结直肠癌肝、肺转移的关系
DOI：
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发表时间：
1990
影响因子：
3.9
通讯作者：
A. Wakizaka
中科院分区：
文献类型：
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作者：
T. Narisawa;H. Kusaka;Y. Yamazaki;M. Takahashi;H. Koyama;Kenji Koyama;Y. Fukaura;A. Wakizaka
前列腺素E2在各种肿瘤中大量产生，由于其不同的病理生理电位，我们在44例结直肠癌患者中研究了其与血液远处转移的关系。作者发现pge2在引流癌的局部静脉血和肝或肺转移病例的外周血中含量显著升高，并且在癌组织中产生大量的pge2。提示局部血pge2升高可促进结直肠癌转移形成，外周血pge2升高可能有助于结直肠癌转移的检测。
The relationship of prostaglandin E2,of which a large amount is produced in various neoplasms, and hematogenous distant metastases was investigated in a total of 44 colorectal cancer patients because of its varied pathophysiologic potentials. The authors found significantly high levels of PGE2in local venous blood draining the carcinoma and in peripheral blood in cases with liver or lung metastasis, as well as a significantly large amount of PGE2production in the carcinoma tissue. The results suggest that increased local blood PGE2could enhance the metastasis formation, and increased peripheral blood PGE2may be useful in the detection of such metastasis in colorectal cancer.
影响因子：
11.2
作者：
C. Osborne;K. Hobbs;G. Clark
通讯作者：
C. Osborne;K. Hobbs;G. Clark