Effects of Persantin (RA8), A New Coronary Vasodilator, on Coronary Blood Flow and Cardiac Dynamics in the Dog
Effects of Persantin (RA8), A New Coronary Vasodilator, on Coronary Blood Flow and Cardiac Dynamics in the Dog
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新型冠状血管扩张剂 Persantin (RA8) 对狗冠状动脉血流和心脏动力学的影响
DOI：
10.1161/01.res.10.1.35
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发表时间：
1962
影响因子：
20.1
通讯作者：
Ottto F. Müller
中科院分区：
文献类型：
--
作者：
J. W. West;S. Bellet;U. Manzoli;Ottto F. Müller
一种新型冠状动脉血管扩张剂（Persantin）在不增加心脏收缩力或心脏工作的情况下显著增加冠状动脉血流量（在正常动物中可达159%），其效果已在实验动物中进行了研究。这与冠状动脉阻力的显著降低有关。冠状静脉氧含量升高，冠状动脉a - v氧差减小；心输出量只受到轻微影响。在通过冠状动脉结扎和应用酪蛋白环缩小冠状动脉管腔而产生充足冠状动脉的犬中，冠状动脉血流量也观察到增加。这并不伴随着心脏工作的显著增加。
The effect of a new coronary vasodilator (Persantin), which produces a marked increase in coronary blood flow (up to 159 per cent in normal animals) without increasing cardiac contractility or cardiac work, has been studied in the experimental animal. This is associated with a marked decrease in coronary resistance. There is an increase in the coronary venous oxygen content and a decrease in the coronary A-V oxygen difference; the cardiac output is only slightly affected. Increase in the coronary blood flow has also been observed in dogs in which coronary in sufficiency has been produced by coronary ligation and by narrowing of the lumen of the coronary artery by the application of casein rings. This was accompanied by no significant increase in cardiac work.