Black raspberries in cancer clinical trials: Past, present and future.
Black raspberries in cancer clinical trials: Past, present and future.
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DOI：
10.3233/jbr-160125
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发表时间：
2016
影响因子：
1.7
通讯作者：
Stoner GD
中科院分区：
文献类型：
--
作者：
Kresty LA;Mallery SR;Stoner GD
黑树莓(BRB)在临床前模型中抑制多种癌症，包括口腔癌、食道癌、结肠癌、乳腺癌和皮肤癌的体内模型。有希望的临床前结果已导致对癌症患者或癌症发展风险增加的患者进行临床评估。总结针对癌症或癌前病变的BRB的临床研究，并讨论未来的方向。进行了全面的文献搜索，直到2015年12月1日，以确定所有发表的在癌症为重点的临床试验中评估BRB的研究。在临床环境中调查BRB的研究报告了对癌前病变或口腔、食道和结肠癌的积极作用。BRB治疗的结果是：口腔上皮内瘤变组织学消退，组织学分级得到改善，肿瘤抑制基因位点杂合性丢失显著减少；在结肠，BRB抑制了FAP相关的息肉进展，使肿瘤抑制基因去甲基化，改善了血浆细胞因子谱；在Barrett病患者中，BRB的消费增加了组织中GST-pi的水平，降低了脂质过氧化/氧化应激标志8-异前列腺素的水平。BRB用于抗癌的确切剂量、持续时间和最佳给药方式仍有待充分阐明。所有研究的共同主题支持BRB具有抗增殖、抗炎、减少氧化应激和恢复肿瘤抑制活性。结论部分包括未来的方向。
Black raspberries (BRB) inhibit a broad range of cancers in preclinical models, including in vivo models of oral, esophageal, colon, breast and skin cancer. Promising preclinical results have led to clinical evaluations in cancer patients or patients at increased risk for cancer development. To summarize clinical investigations targeting cancer or precancerous lesions with BRB and discuss future directions. A thorough literature search was conducted through December 1, 2015 to identify all published studies evaluating BRB in cancer focused clinical trials. Research investigating BRB in clinical settings report positive effects on preneoplastic lesions or cancers of the oral cavity, esophagus and colon. BRB treatment resulted in: histologic regression of oral intraepithelial neoplasia associated with improved histologic grade and significantly reduced loss of heterozygosity at tumor suppressor gene loci, modulated genes linked to RNA processing and growth factor recycling; in the colon, BRB inhibited FAP-associated polyp progression, demethylated tumor suppressor genes and improved plasma cytokine profiles; in Barrett’s patients, BRB consumption increased tissue levels of GST-pi and decreased 8-isoprostane, a marker of lipid peroxidation/oxidative stress. The precise dose, duration and optimum mode of BRB delivery for cancer inhibition remains to be fully elucidated. Common themes across studies support that BRB are anti-proliferative, anti- inflammatory, reduce oxidative stress and restore tumor suppressive activity. Future directions are included in the conclusions section.