PERIVENTRICULAR LEUKOMALACIA - A ONE-YEAR AUTOPSY STUDY
PERIVENTRICULAR LEUKOMALACIA - A ONE-YEAR AUTOPSY STUDY
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DOI：
10.1001/archneur.1980.00500530069011
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发表时间：
1980-01-01
影响因子：
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通讯作者：
SELEDNIK, LJ
中科院分区：
文献类型：
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作者：
SHUMAN, RM;SELEDNIK, LJ
连续12个月新生儿尸检中脑室周围白质软化（PVL）的频率和分布。期间进行了审查。88%的高危儿发生脑室周围白质软化。定义风险的人口统计学因素是出生体重在900-2200 g之间，存活6天或更长时间。几乎所有PVL婴儿均遭受严重的临床损伤，和/或内脏有其他坏死性病变。PVL发生于枕叶和感觉运动放射区的脑轴突。在尸检中发现这种病变的频率可能与存活的早产儿发生视觉、听觉和运动功能障碍的频率相对应。对高危早产儿进行电生理检查似乎是必要的。
The frequency and distribution of periventricular leukomalacia (PVL) in consecutive neonatal autopsies in a complete 12 mo. period was reviewed. Periventricular leukomalacia occurred in 88% of the high-risk infants. The demographic factors that define risk are a birth weight between 900-2200 g and a survival of 6 days or more. Virtually all infants with PVL suffered severe clinical insults, and/or had additional necrotic lesions in their viscera. Preferentially, PVL occurs in the cerebral axons in the occipital and sensory-motor radiations. The frequency with which this lesion is found at autopsy may correspond to the frequency with which visual, auditory and motor dysfunctions occur in surviving premature infants. Electrophysiologic investigations of the high-risk premature infant seem warranted.