A combined frequency domain near infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading.
A combined frequency domain near infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading.
复制标题
组合频域近红外光谱和漫相关光谱系统，用于加载期间吸气肌的全面代谢监测。
DOI：
10.1101/2023.11.30.569133
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Roblyer,Darren
中科院分区：
文献类型：
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作者：
Gómez,CarlosA;Brochard,Laurent;Goligher,EwanC;Rozenberg,Dmitry;Reid,WDarlene;Roblyer,Darren
重要性机械通气（MV）是重症监护病房的基石技术，因为它有助于为危重患者输送氧气。使患者脱离MV的过程可能是漫长而艰巨的，并且可能导致许多患者的严重并发症。尽管已知吸气肌功能在成功断奶中的重要性，目前的临床标准不包括直接监测这些肌肉。目的本项目的目标是开发和验证组合频域近红外光谱（FD-NIRS）和扩散相关光谱（DCS）系统的非侵入性表征吸气肌对负荷的反应。ApproachThe系统是由定制的数字FD-NIRS和DCS系统相结合。通过液体体模滴定和健康志愿者研究对其进行了验证。对14名年轻健康志愿者的胸锁乳突肌（SCM）进行了短负荷监测。志愿者进行了两种不同的呼吸练习，一个中等负荷和高负荷，其中包括一分钟的基线，一分钟的负荷，和一个6分钟的恢复期。ResultsThe系统具有较低的串扰之间的吸收，减少散射，和流量测试时，在一组液体滴定。与基于血红蛋白+肌红蛋白（Hb+Mb）的参数相比，在雄性动物开始负荷后，观察到血流指数（）和氧代谢率（）变化的动力学更快。此外，与Hb+Mb参数相比，在雄性和雌性中观察到较大的百分比变化。氧合血红蛋白+Mb，总血红蛋白+Mb，和tissue saturation. ConclusionsHb +Mb浓度和血流量的动态特性的基线值也有性别差异，在SCM的负载过程中是不同的，这表明FD-NIRS和DCS的组合可以提供一个更完整的图片吸气肌肉动力学。
SignificanceMechanical ventilation (MV) is a cornerstone technology in the intensive care unit as it assists with the delivery of oxygen in critically ill patients. The process of weaning patients from MV can be long and arduous and can lead to serious complications for many patients. Despite the known importance of inspiratory muscle function in the success of weaning, current clinical standards do not include direct monitoring of these muscles.AimThe goal of this project was to develop and validate a combined frequency domain near-infrared spectroscopy (FD-NIRS) and diffuse correlation spectroscopy (DCS) system for the noninvasive characterization of inspiratory muscle response to a load.ApproachThe system was fabricated by combining a custom digital FD-NIRS and DCS system. It was validated via liquid phantom titrations and a healthy volunteer study. The sternocleidomastoid (SCM), an accessory muscle of inspiration, was monitored during a short loading period in fourteen young, healthy volunteers. Volunteers performed two different respiratory exercises, a moderate load and a high load, which consisted of a one-minute baseline, a one-minute load, and a six-minute recovery period.ResultsThe system has low crosstalk between absorption, reduced scattering, and flow when tested in a set of liquid titrations. Faster dynamics were observed for changes in blood flow index (), and metabolic rate of oxygen () compared with hemoglobin + myoglobin (Hb+Mb) based parameters after the onset of loads in males. Additionally, larger percent changes in, andwere observed compared with Hb+Mb parameters in both males and females. There were also sex differences in baseline values of oxygenated Hb+Mb, total Hb+Mb, and tissue saturation.ConclusionsThe dynamic characteristics of Hb+Mb concentration and blood flow were distinct during loading of the SCM, suggesting that the combination of FD-NIRS and DCS may provide a more complete picture of inspiratory muscle dynamics.