DNA modifications and genome rearrangements during the development and sex differentiation of the bumble bee Bombus terrestris
DNA modifications and genome rearrangements during the development and sex differentiation of the bumble bee Bombus terrestris
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DOI：
10.1111/j.1365-2583.2010.01052.x
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发表时间：
2011-04-01
影响因子：
2.6
通讯作者：
Tasei, J. -N.
中科院分区：
文献类型：
--
作者：
Bigot, Y.;Jegot, G.;Tasei, J. -N.
土蜂是一种大黄蜂，像大多数膜翅目物种一样，表现出由单一性别基因控制的倍性特异性性别决定。根据它们的倍性和蜂后信息素的抑制程度，这些蜂像分为三个等级：雄性、工蜂和蜂后。在这里，我们集中在基因组组织的差异，发生在发育和性别分化。我们发现胞嘧啶甲基化是一个重要的表观遗传因素，其特征可以与这两个过程相关。我们还发现有两种类型的基因组重排发生。第一个由重要的DNA扩增组成，其序列谱在不同的发育阶段和性别中是不同的。在第二类中，也会发生DNA损失，至少涉及到镶嵌转座元件B. terrestris mosaic repeat 1 （BTMR1）。
Bombus terrestris is a bumble bee that, like most hymenopteran species, exhibits ploidy-specific sex determination controlled by a single sex gene. Depending on their ploidy and the queen pheromone repression, the imagoes differentiate into three castes: males, workers and queens. Here, we focus on the differences of genome organization that occur during development and sex differentiation. We found that cytosine methylation is a significant epigenetic factor with profiles that can be correlated with both processes. We also showed that two kinds of genomic rearrangement occur. The first consists of important DNA amplifications that have sequence profiles that differ in the different developmental instars and sexes. In the second kind, DNA losses also occur, at least involving the mosaic transposable element B. terrestris mosaic repeat 1 (BTMR1).