Intensity of the Humoral Response to Cytomegalovirus Is Associated with the Phenotypic and Functional Status of the Immune System
Intensity of the Humoral Response to Cytomegalovirus Is Associated with the Phenotypic and Functional Status of the Immune System
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DOI：
10.1128/jvi.02425-12
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发表时间：
2013-04-01
影响因子：
5.4
通讯作者：
Lopez-Larrea, C.
中科院分区：
文献类型：
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作者：
Alonso Arias, R.;Moro-Garcia, M. A.;Lopez-Larrea, C.
巨细胞病毒（CMV）感染对人体免疫产生巨大影响，因为它与免疫受损反应、多种慢性疾病和老年人的总体生存率有关。抗巨细胞病毒抗体水平可能与T细胞亚群的分化程度有关。老年人的滴度明显更高，并且与CD4(+) T细胞对CMV的特异性反应呈正相关。在老年人中，抗体滴度与CD4(+) T细胞的分化程度和T细胞受体切除圈（TREC）含量有关，与免疫风险谱的其他特征有关，并且与体内免疫应答能力降低有关。相关性可能在年轻受试者中不存在，因为他们的抗巨细胞病毒抗体滴度低于老年人。然而，比较具有相似抗体水平的年轻人和老年人揭示了他们高度分化和幼稚T细胞的差异。这些在高滴度的个体中更为明显。在抗巨细胞病毒抗体增加的同时，老年人的初始CD4(+) T细胞绝对计数显著减少，这可能是一种补偿分化细胞扩增和避免总T细胞增加的策略。综上所述，我们的研究结果表明，抗巨细胞病毒抗体滴度，而不仅仅是巨细胞病毒血清阳性，与老年人的分化状态和免疫能力有关，使其成为免疫系统功能状态的重要预后指标。
Cytomegalovirus (CMV) infection exerts an enormous effect on human immunity, as it is associated with an immune-impaired response, a variety of chronic diseases, and overall survival in elderly individuals. Levels of anti-CMV antibodies may be associated with the differentiation degree of T cell subsets. Titers are significantly higher in the elderly and positively correlated with specific CD4(+) T cell responses to CMV. In the elderly, antibody titers are associated with the degree of differentiation and the T cell receptor excision circle (TREC) content in CD4(+) T cells, with other features of the immune risk profile, and with a reduced ability to respond to immunization in vivo. Associations may be absent in young subjects because their anti-CMV antibody titers are lower than those of the elderly. However, comparing young and elderly individuals with similar antibody levels reveals differences in their highly differentiated and naive T cells. These are more marked in individuals with high titers. In parallel with the increase in anti-CMV antibodies, the elderly experience a significant reduction in absolute counts of naive CD4(+) T cells, which may be a strategy to compensate for the expansion of differentiated cells and to avoid an increase in total T cells. In summary, our results show that titers of anti-CMV antibodies, and not only CMV seropositivity, are related to differentiation status and immunocompetence in the elderly, making this as an important prognostic marker of the status of immune system function.