Structural variations in crocodile lizard populations provide novel insights into genomic variations in endangered animals
Structural variations in crocodile lizard populations provide novel insights into genomic variations in endangered animals
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DOI：
10.1111/mec.17141
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发表时间：
2023-09-23
影响因子：
4.9
通讯作者：
Jiang，Yuxin
中科院分区：
文献类型：
--
作者：
Xiong，Lei;Zhou，Zeshuo;Jiang，Yuxin
对濒危动物进行种群规模的基因组重测序可能有助于了解基因组如何随着种群规模变小而变化，以及这种变化的功能影响。在这项研究中，我们分析了濒临灭绝的鳄鱼蜥蜴种群基因组的结构变异和基因存在和缺失的变异。我们发现，一些基因的频率在不同地区的鳄鱼蜥蜴之间表现出显着差异，这表明环境选择的影响，以及人口统计学和隔离对基因存在和缺失变异的潜在贡献。研究还发现，居住在不同地区的鳄鱼蜥蜴的主要组织相容性复合体（MHC）基因的单倍型多样性存在差异。这些发现表明，来自不同地区的鳄鱼蜥蜴经过精心设计的杂交可能会促进不同蜥蜴种群之间的基因交换，并增加MHC基因的单倍型多样性，这可能有利于这些蜥蜴的生存。我们在这项研究中的发现基于基因结构变异的差异，为基因组变异提供了新的见解，并可能有助于保护濒危动物。
Population‐scale genome resequencing of endangered animals may contribute to gaining an understanding of how genomes vary as population sizes become smaller, as well as the functional implications of such variation. In this study, we analysed structural variations and gene presence and absence variations in the genomes of population of the endangered crocodile lizards. We found that the frequencies of some genes showed significant differences between crocodile lizards in different regions, indicating the influence of environmental selection, as well as potential contributions from demography and isolation, in shaping gene presence and absence variations. The haplotype diversity of major histocompatibility complex (MHC) genes was also found to differ among crocodile lizards inhabiting different regions. These findings indicate that well‐designed interbreeding of crocodile lizards from different regions may facilitate the exchange of genes between different lizard populations and increase the haplotype diversity of MHC genes, which may be beneficial for the survival of these lizards. Our findings in this study, based on differences in gene structural variation, provide new insights into genomic variation and may contribute to the conservation of endangered animals.