Voice-related quality of life in T1 glottic cancer: Irradiation versus endoscopic excision
Voice-related quality of life in T1 glottic cancer: Irradiation versus endoscopic excision
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DOI：
10.1177/000348940611500803
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发表时间：
2006-08-01
影响因子：
1.4
通讯作者：
Courey, Mark S.
中科院分区：
文献类型：
--
作者：
Cohen, Seth M.;Garrett, C. Gaelyn;Courey, Mark S.
目的：几项研究探讨了早期声门癌治疗后的声音结果，但结果各不相同。为了进一步明确接受外照射放射治疗 (EBRT) 与内镜二氧化碳激光切除术 (CLE) 治疗的 T1 声门癌患者的声音相关生活质量 (QOL)，我们进行了荟萃分析。方法：我们对 1966 年至 2005 年的声音障碍指数 (VHI)、喉癌、声音结果、声音质量和生活质量进行了荟萃分析。通过荟萃分析技术确定并分析了在 T1 声门癌治疗后至少 3 个月评估 VHI 的研究。 结果：确定了 6 项研究，涉及 208 名接受 CLE 治疗的患者（6 名 T1b 和 202 名 T1a）以及 91 名接受 EBRT 治疗的患者（6 名 T1b 和 85 名 T1a）。 EBRT 和 CLE 治疗患者的治疗后 VHI 评分相似（p = 0.1，Wilcoxon 秩和检验）。结论：我们得出结论，CLE 和 EBRT 为 T1 声门癌患者提供了相当水平的声音障碍。
Objectives: Several studies have explored posttreatment voice outcomes for early glottic cancer with varying results. To further clarify the voice-related quality of life (QOL) of T1 glottic cancer patients treated by external beam radiotherapy (EBRT) compared to endoscopic carbon dioxide laser excision (CLE), we performed a meta-analysis.Methods: We performed a meta-analysis review for the years 1966 to 2005 for the Voice Handicap Index (VHI), laryngeal cancer, voice outcome, voice quality, and quality of life. Studies in which the VHI was assessed at least 3 months after treatment for T1 glottic cancer were identified and analyzed by meta-analysis techniques.Results: Six studies with 208 patients (6 T1b and 202 T1a) treated with CLE and 91 patients (6 T1b and 85 T1a) treated with EBRT were identified. The posttreatment VHI scores were similar for the EBRT- and CLE-treated patients (p = .1, Wilcoxon rank sum test).Conclusions: We conclude that CLE and EBRT provide comparable levels of voice handicap for patients with T1 glottic cancer.