Mesenteric and splenic cat-scratch disease during etanercept therapy.
Mesenteric and splenic cat-scratch disease during etanercept therapy.
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依那西普治疗期间的肠系膜和脾脏猫抓病。
作者：
A. Schiffmann;Y. Pers;C. Lukas;B. Combe;J. Morel
基因芯片研究、严格的统计分析和实时聚合酶链式反应(Real-Time-PCR)的验证，让我们对我们的发现充满信心。尽管MMPmRNA可能与组织中的蛋白浓度或酶活性不完全相关[10]，但我们的研究结果表明，MMP9和MMP12在GCA发病机制中的潜在作用值得进一步研究。在推测它们作为治疗靶点之前，需要进行功能研究以确定这两种酶在GCA动脉损伤发生中的具体作用(S)。需要进行临床研究，以确定GCA患者血清中这些MMPs水平是否升高。如果是这样的话，我们的初步发现可能对GCA的诊断有意义。
microarray study, the stringent statistical analysis used and the validation using real-time-PCR give us confidence in our findings. Although MMP mRNA may not correlate perfectly with protein concentration in tissues or enzymatic activity [10], our findings suggest that the potential role of MMP-9 and -12 in GCA pathogenesis deserves further study. Functional studies are needed to determine the specific contribution of these two enzymes in the development of arterial damage in GCA before any conjecture about their use as therapeutic target(s) can be made. Clinical studies will be required to determine whether serum levels of these MMPs are elevated in GCA patients. If so, our preliminary findings might have implications for diagnosis of GCA.