Improved Glaucoma Medication Adherence in a Randomized Controlled Trial
Improved Glaucoma Medication Adherence in a Randomized Controlled Trial
复制标题
DOI：
10.1016/j.ogla.2021.04.006
复制
发表时间：
2022-01-20
影响因子：
2.9
通讯作者：
Bosworth, Hayden B.
中科院分区：
文献类型：
--
作者：
Muir, Kelly W.;Rosdahl, Jullia A.;Bosworth, Hayden B.
目的：为了测试旨在改善青光眼药物依从性的干预措施的有效性。设计：在退伍军人事务部（VA）眼科诊所进行的随机对照试验。参与者：患有药物治疗青光眼的退伍军人，他们报告依从性差，如果适用，还有他们的同伴。方法：参与者和他们的同伴（如果适用）被随机分配接受干预，以改善药物依从性，包括青光眼教育，个性化的疾病管理建议和提醒援助，或对照组接受教育，关于一般眼健康。主要结果措施：平均比例的规定青光眼药物剂量采取的时间表超过6个月后，随机化，根据电子监测器之间的参与者在两个武器。结果：与对照组相比，干预组按计划服用处方剂量的平均比例较高（0.85 vs. 0.62，P < 0.0001）。在根据伴侣状态、给药频率和人种校正的回归模型中，2组之间的比例差异无变化。纵向模型表明，干预组在随机化后的第一个月内具有显著较高的依从性，并在6个月内继续保持较高的依从性（治疗相互作用的月，P = 0.003）。结论：多方面的干预有助于提高青光眼药物依从性。(C)2021年美国眼科学会
Purpose: To test the effectiveness of an intervention designed to improve glaucoma medication adherence.Design: Randomized, controlled trial at a Veterans Affairs (VA) eye clinic.Participants: Veterans with medically treated glaucoma who reported poor adherence and their companions if applicable.Methods: Participants, and their companions if applicable, were randomized to receive an intervention to improve medication adherence that included glaucoma education, personalized disease management suggestions, and a reminder aid, or the control arm that received education regarding general eye health.Main Outcome Measures: The average proportion of prescribed glaucoma medication doses taken on schedule over the 6 months after randomization according to an electronic monitor between participants in the 2 arms.Results: The mean proportion of prescribed doses taken on schedule was higher in the intervention group compared with controls (0.85 vs. 0.62, P < 0.0001). The difference in proportions between the 2 groups did not vary in regressions models adjusted for companion status, frequency of dosing, and race. The longitudinal model indicated that the intervention group had significantly higher adherence during the first month after randomization and continued to stay higher through 6 months (month by treatment interaction, P = 0.003).Conclusions: A multifaceted intervention can help improve glaucoma medication adherence. (C) 2021 by the American Academy of Ophthalmology