Melatonin mediates two distinct responses in vascular smooth muscle
Melatonin mediates two distinct responses in vascular smooth muscle
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DOI：
10.1016/s0014-2999(98)00064-8
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发表时间：
1998-03-12
影响因子：
5
通讯作者：
Duckles, SP
中科院分区：
文献类型：
--
作者：
Doolen, S;Krause, DN;Duckles, SP
松果体褪黑激素在血管平滑肌中产生两种不同的收缩反应。在离体大鼠尾动脉段，去内皮后，褪黑素(10（-10)-10(-7)M）以浓度依赖的方式增强苯肾上腺素诱导的收缩。然而，在较高的褪黑激素浓度(10（-7)-10(-5)M）下，增强效应减弱。在褪黑激素MT2受体拮抗剂4-苯基-2-乙酰氨基四胺（4P-ADOT）的存在下，减弱的收缩反应选择性地增强。这些结果与褪黑素激活血管平滑肌中两种受体亚型的假设一致；MT2受体可诱导松弛，而第二受体亚型介导血管收缩。(C) 1998爱思唯尔科学有限公司
The pineal hormone melatonin was found to produce two distinct contractile responses in vascular smooth muscle. In isolated rat caudal artery segments, denuded of endothelium, melatonin (10(-10)-10(-7) M) potentiated phenylephrine-induced contractions in a concentration-dependent manner. At higher melatonin concentrations (10(-7)-10(-5) M). however, the potentiating effect was attenuated. In the presence of the melatonin MT2 receptor antagonist, 4-phenyl-2-acetamidotetraline (4P-ADOT), the attenuated constrictor responses were selectively enhanced. These results are consistent with the hypothesis that melatonin activates two receptor subtypes in vascular smooth muscle; MT2 receptors may induce relaxation, while a second receptor subtype mediates vasoconstriction. (C) 1998 Elsevier Science B.V.