Perirhinal cortex damage and anterograde object-recognition in rats after long retention intervals
Perirhinal cortex damage and anterograde object-recognition in rats after long retention intervals
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DOI：
10.1016/j.bbr.2007.07.026
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发表时间：
2007-12-28
影响因子：
2.7
通讯作者：
Lehmann, Hugo
中科院分区：
文献类型：
--
作者：
Mumby, Dave G.;Piterkin, Pavel;Lehmann, Hugo
大鼠的外周皮质（PRh）损伤在长达数小时的保留间隔后会损害顺行性物体识别记忆，但很少有直接证据表明，在长达数天或数周的较长时间间隔后，PRh功能与物体识别能力之间存在联系。我们使用新物体偏好测试评估了PRh病变对顺行性物体识别的影响，保留间隔为24小时和3周。在学习阶段，大鼠连续5天，每天5分钟，多次接触样物。对照大鼠在两种保留间隔后都表现出明显的新物体偏好，表明对样本物体的识别，而PRh病变大鼠在24小时间隔后表现出明显的偏好，但在3周间隔后没有表现出明显的偏好。当试验的学习阶段缩短为单个5分钟时，PRh组在24小时的情况下受到损害。研究结果表明，PRh损伤对顺行性物体识别的破坏性影响在学习后的很长时间内持续存在。结果进一步表明，PRh损伤后的物体识别障碍并不普遍存在，学习条件对PRh损伤大鼠的后续识别表现起重要作用。(C) 2007 Elsevier B.V.版权所有
Damage to the perithinal cortex (PRh) in rats impairs anterograde object-recognition memory after retention intervals of up to several hours, but there is little direct evidence to link PRh function to object-recognition abilities after substantially longer intervals that span several days or weeks. We assessed the effects of PRh lesions on anterograde object recognition using a novel-object preference test, with retention intervals lasting 24 h and 3 weeks. The rats received multiple exposures to the sample object during the learning phase-5 min per day on 5 consecutive days. Control rats displayed a significant novel-object preference after both retention intervals, indicating recognition of the sample object, whereas the rats with PRh lesions displayed a significant preference after the 24-h interval, but not after the 3-week interval. When the learning phase of the trial was shortened to a single 5-min session, the PRh group was impaired in the 24-h condition. The findings indicate that the disruptive effects of PRh damage on anterograde object recognition persist over very long postlearning intervals. The results indicate further that object recognition impairments following PRh damage are not ubiquitous, and that learning conditions play a significant role in determining the subsequent recognition performance in rats with PRh damage. (C) 2007 Elsevier B.V. All rights reserved.