Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: A promising male contraceptive approach
Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: A promising male contraceptive approach
复制标题
DOI：
10.1210/jc.81.2.757
复制
发表时间：
1996-02-01
影响因子：
5.8
通讯作者：
Matsumoto, AM
中科院分区：
文献类型：
--
作者：
Bebb, RA;Anawalt, BD;Matsumoto, AM
在正常男性中使用高剂量睾酮 (T) 作为男性避孕药的研究表明，无精子症发生率仅为 50-70%。先前对 T 和孕激素组合的研究显示，无精子症的发生率相当，但未受控制或使用 T 的剂量低于与最大程度抑制精子产生相关的剂量。我们进行了一项随机、安慰剂对照、单盲试验，对 36 名年龄 20-42 岁的正常男性（每组 n = 18）进行 6 个月的 T 庚酸给药（100 毫克，肌肉注射，每周）与相同剂量的 T 庚酸联合孕激素左炔诺孕酮（LNG；500 微克，口服，每日）进行比较。主要终点是诱导无精子症或严重少精子症（
Studies using high dose testosterone (T) administration in normal men as a male contraceptive have resulted in azoospermia rates of only 50-70%. Previous studies of T and progestogen combinations have shown comparable rates of azoospermia, but have been uncontrolled or used T in doses less than that associated with maximal suppression of sperm production. We conducted a randomized, placebo-controlled, single blind trial comparing 6 months of T enanthate administration (100 mg, im, weekly) with the same dose of T enanthate in conjunction with the progestogen levonorgestrel (LNG; 500 mu g, orally, daily) in 36 normal men, aged 20-42 yr (n = 18 in each group). The primary end points were induction of azoospermia pr severe oligospermia (