Polymeric Materials for Gene Delivery and DNA Vaccination.
Polymeric Materials for Gene Delivery and DNA Vaccination.
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DOI：
10.1002/adma.200801478
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发表时间：
2009-02-23
期刊：
影响因子：
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通讯作者：
Anderson DG
中科院分区：
文献类型：
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作者：
Nguyen DN;Green JJ;Chan JM;Longer R;Anderson DG
Gene delivery holds great potential for the treatment of many different diseases. Vaccination with DNA holds particular promise, and may provide a solution to many technical challenges that hinder traditional vaccine systems including rapid development and production and induction of robust cell-mediated immune responses. However, few candidate DNA vaccines have progressed past preclinical development and none have been approved for human use. This Review focuses on the recent progress and challenges facing materials design for nonviral DNA vaccine drug delivery systems. In particular, we highlight work on new polymeric materials and their effects on protective immune activation, gene delivery, and current efforts to optimize polymeric delivery systems for DNA vaccination.
