Diet and childhood asthma in a society in transition: a study in urban and rural Saudi Arabia
Diet and childhood asthma in a society in transition: a study in urban and rural Saudi Arabia
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DOI：
10.1136/thorax.55.9.775
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发表时间：
2000-09-01
期刊：
影响因子：
10
通讯作者：
Seaton, A
中科院分区：
文献类型：
--
作者：
Hijazi, N;Abalkhail, B;Seaton, A
世界范围内儿童哮喘和过敏性疾病增加的原因尚不清楚，这些疾病似乎与日益繁荣有关。我们先前假设，减少。饮食中的抗氧化成分是一个重要因素。在沙特阿拉伯对哮喘的饮食和其他危险因素进行了调查，在不同的社区发现了主要的生活方式差异和过敏性疾病的患病率。方法：从吉达和沙特农村的1444名平均年龄为12岁（SD 1）的儿童的横断面研究中，我们选择了114例在过去12个月内有哮喘和喘息病史的儿童，以及202例从未抱怨过喘息或哮喘的对照，记录在ISAAC问卷上。通过问卷调查确定哮喘和过敏的危险因素（家族史、社会阶层、感染、免疫接种、家庭规模和饮食）。皮肤点刺试验评估特应性。结果：在单变量分析中，家族史、特应性反应和吃快餐是哮喘疾病的重要危险因素，牛奶和蔬菜、纤维、维生素E、钙、镁、钠和钾的摄入量最低也是重要危险因素。这些差异在单独考虑的城市儿童中也存在。性别、家庭规模、社会阶层、感染和父母吸烟与风险无关。在多元logistic回归分析中，城市居住、皮肤试验阳性、过敏性疾病家族史以及维生素E、镁和钠的最低摄入量与风险显著且独立相关。当校正其他因素后，维生素E摄入量最低的分位数与三倍（95%可信区间1.38至6.50）的风险增加相关。牛奶和蔬菜的摄入量都与病例呈反比线性关系。结论：本研究表明，在考虑城乡居住、性别、家族史和特应性因素后，儿童时期的饮食因素是决定喘息疾病表达的重要影响因素。这一发现与之前对成人的研究一致，也与饮食变化是全球哮喘和过敏病例增加的决定因素的假设一致。
Background-The causes of the worldwide increases in asthma and allergic diseases in childhood, which seem to relate to increasing prosperity, are unknown. We have previously hypothesised that a reduction iu. the antioxidant component of the diet is an important factor. An investigation was undertaken of dietary and other risk factors for asthma in Saudi Arabia where major Lifestyle differences and prevalences of allergic disease are found in different communities.Methods-From a cross sectional study of 1444 children with a mean age of 12 (SD 1) years in Jeddah and a group of rural Saudi villages, we selected 114 cases with a history of asthma and wheeze in the last 12 months and 202 controls who had never complained of wheeze or asthma, as recorded on the ISAAC questionnaire. Risk factors for asthma and allergies (family history social class, infections, immunisations, family size, and diet) were ascertained by questionnaire. Atopy was assessed by skin prick testing.Results-In univariate analyses, family history, atopy, and eating at fast food outlets were significant risk factors for wheezy illness, as were the lowest intakes of milk and vegetables and of fibre, vitamin E, calcium, magnesium, sodium, and potassium. These differences were present also in the urban children considered separately. Sex, family size, social class, infections, and parental smoking showed no relationship to risk. In multiple logistic regression analysis, urban residence, positive skin tests, family history of allergic disease, and the lowest intakes of vitamin E, magnesium and sodium related significantly and independently to risk. The lowest tertile of intake of vitamin E was associated with a threefold (95% CI 1.38 to 6.50) increase in risk when adjusted for the other factors. Intake of milli and vegetables both showed inverse Linear relationships to being a case.Conclusions-This study suggests that dietary factors during childhood are an important influence in determining the expression of wheezy illness, after allowing for urban/rural residence, sex, family history and atopy. The findings are consistent with previous studies in adults and with the hypothesis that change in diet has been a determinant of the worldwide increases in asthma and allergies.