How many sexually-acquired HIV infections in the USA are due to acute-phase HIV transmission?
How many sexually-acquired HIV infections in the USA are due to acute-phase HIV transmission?
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DOI：
10.1097/qad.0b013e32826fb6a6
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发表时间：
2007-07-31
期刊：
影响因子：
3.8
通讯作者：
Pinkerton, Steven D.
中科院分区：
文献类型：
--
作者：
Pinkerton, Steven D.
目的：估计美国因与急性感染的性伴侣进行危险性活动而感染艾滋病毒的人数。方法：对美国急性期HIV传播引起的新发感染数量的估计来自一个简单的数学模型，该模型将流行病学数据与急性感染、非急性感染但血清状态不明的相对传播率信息相结合，和血清学状态意识的人与HIV。结果大约2760（8.6%）的估计32000性获得的HIV感染，每年在美国是由于急性期传播的病毒。多变量敏感性分析与自由范围的值的关键参数产生的上限为5537感染，占17.3%的性获得性infecties.Conclusions总数的急性期HIV传播占较少的性获得性感染在美国比一般假设。(c)2007年利平科特威廉姆斯&威尔金斯。
Objective: To estimate the number of persons in the USA who acquire HIV as a consequence of risky sexual activities with an acutely-infected sex partner.Methods: Estimates of the number of incident infections in the USA that are due to acute-phase HIV transmission were derived from a simple mathematical model that combined epidemiological data with information regarding the relative transmission rates for acutely-infected, nonacutely infected but serostatus-unaware, and serostatus-aware persons living with HIV.Results Approximately 2760 (8.6%) of the estimated 32000 sexually-acquired HIV infections in the USA each year are due to acute-phase transmission of the virus. Multivariate sensitivity analyses with a liberal range of values for key parameters produced an upper bound of 5537 infections, representing 17.3% of the total number of sexually-acquired infections.Conclusions Acute-phase HIV transmission accounts for fewer sexually-acquired infections in the USA than is generally assumed. (c) 2007 Lippincott Williams & Wilkins.