BRAIN 5-HT2 RECEPTOR-BINDING SITES IN DEPRESSED SUICIDE VICTIMS
BRAIN 5-HT2 RECEPTOR-BINDING SITES IN DEPRESSED SUICIDE VICTIMS
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DOI：
10.1016/0006-8993(88)91621-6
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发表时间：
1988-03-08
期刊：
影响因子：
2.9
通讯作者：
HORTON, RW
中科院分区：
文献类型：
--
作者：
CHEETHAM, SC;CROMPTON, MR;HORTON, RW
对19例有明确抑郁症证据的自杀者和19例性别、年龄相匹配的对照组的死后脑组织进行了5-HT2受体结合位点的测定(用饱和结合法)。其中5名自杀受害者在死前接受了抗抑郁药物治疗；13名自杀受害者最近没有服用抗抑郁药物或其他精神活性药物，死后血液中也没有发现任何药物。抑郁症自杀者与对照组相比，额叶、颞叶、枕叶皮质和杏仁核的5-HT2结合位点数目无显著差异，无论是完全自杀组还是非抑郁自杀组。在完全自杀组中，海马区5-HT2结合位点的数量与对照组没有差异，但在不服用抗抑郁药的自杀组中，5-HT2结合位点的数量显著减少(23%)。在不服用抗抑郁药的自杀者中，[~3H]酮丝氨酸结合的亲和力与对照组没有差异，但在接受抗抑郁药物的受试者中，结合的亲和力较低(增加的Kd)。未发现5-HT2结合位点的数量或亲和力与组织死亡时间、组织保存时间或检测前组织保存时间之间的相关性。研究发现，受试者的年龄与额叶和枕叶皮质中5-HT2结合部位的数量呈显著负相关。目前对有明确抑郁症证据的自杀者的研究并不证实先前关于自杀者5-HT2结合位点数量增加的研究，并表明这些先前的发现可能与抑郁症以外的因素有关。
5-HT2 receptor binding sites were measured (by saturation binding of [3H]ketanserin) in brain tissue obtained at postmortem from 19 suicide victims with definite evidence of depression and 19 sex and age-matched control subjects. Five of the suicide victims were receiving antidepressant drugs prior to death; 13 suicide victims had not been prescribed antidepressant or other psychoactive drugs recently and none were found in their blood at postmortem. The number of serotonin-2(5-HT2) binding sites in frontal, temporal and occipital cortex and amygdala did not differ significantly between the depressed suicide victims and controls, either in the total suicide group or in the antidepresant drug-free suicides. The number of 5-HT2 binding sites in the hippocampus did not differ from controls in the total suicide group but was significantly lower (by 23%) in the antidepressant-free suicide group. The affinity of [3H]ketanserin binding did not differ from controls in the antidepressant-free suicides but was lower (increased Kd) in those subjects receiving antidepressant drugs. No correlation was found bwteen the time of death and storage of tissue or the duration of tissue storage prior to assay and the number or affinity of 5-HT2 binding sites. A significant negative correlation was found between age of the subject and the number of 5-HT2 binding sites in the frontal and occipital cortex. The present study of suicide victims with definite evidence of depression do not confirm previous studies of increased numbers of 5-HT2 binding sites in suicide victims and suggest that these previous findings may be related to factors other than depression.