The dual role of heme as cofactor and substrate in the biosynthesis of carbon monoxide.
The dual role of heme as cofactor and substrate in the biosynthesis of carbon monoxide.
复制标题
血红素在一氧化碳生物合成中作为辅助因子和底物的双重作用。
DOI：
10.1039/bk9781847559159-00241
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Rodríguez,JuanC
中科院分区：
文献类型：
--
作者：
Rivera,Mario;Rodríguez,JuanC
6.结论与展望一氧化碳（CO）是大气中普遍存在的一种分子。哺乳动物、质体和细菌细胞的代谢也产生CO作为由血红素加氧酶（HO）进行的血红素降解的催化循环的副产物。一氧化碳的生物学作用范围从毒性到细胞保护，取决于浓度。由HO的催化活性产生的CO现在已知在几个重要的生理过程中起作用，包括血管舒张、细胞凋亡、炎症和可能的神经传递。因此，了解导致从血红素形成这种重要气体分子的反应的细节已经成为化学研究的一个重要方面，
6. CONCLUSION AND OUTLOOK 284 ACKNOWLEDGMENTS 285 ABBREVIATIONS 286 REFERENCES 286ABSTRACT: Carbon monoxide (CO) is a ubiquitous molecule in the atmosphere. The metabolism of mammalian, plastidic, and bacterial cells also produces CO as a byproduct of the catalytic cycle of heme degradation carried out by the enzyme heme oxygenase (HO). The biological role of CO spans the range from toxic to cytoprotective, depending on concentration. CO generated by the catalytic activity of HO is now known to function in several important physiological processes, including vasodilation, apoptosis, inflammation, and possibly neurotransmission. Consequently, understanding the details of the reaction that leads to the formation of this important gaseous molecule from heme has become an important aspect in the study of the chemistry and