Uptake of pyocin S3 occurs through the outer membrane ferripyoverdine type II receptor of Pseudomonas aeruginosa
Uptake of pyocin S3 occurs through the outer membrane ferripyoverdine type II receptor of Pseudomonas aeruginosa
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DOI：
10.1128/jb.181.12.3849-3851.1999
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发表时间：
1999-06-01
影响因子：
3.2
通讯作者：
Cornelis, P
中科院分区：
文献类型：
--
作者：
Baysse, C;Meyer, JM;Cornelis, P
发现绿脓菌素S3仅杀死产生II型绿脓菌荧光素的铜绿假单胞菌分离株（以菌株ATCC 27853为例）。通过添加II型铁绿荧光素特异性抑制杀伤。所有的Tn5突变体的绿脓菌素S3的耐药是有缺陷的绿脓菌荧光素介导的铁的摄取，并未能产生一个85 kDa的铁抑制外膜蛋白。我们的结论是，这种蛋白质可能是II型ferripyoverdine受体，绿脓菌素S3使用，以获得进入细胞。
Pyocin S3 was found to kill exclusively Pseudomonas aeruginosa isolates producing type II pyoverdine (exemplified by strain ATCC 27853). Killing was specifically inhibited by addition of type II ferripyoverdine. All Tn5 mutants resistant to pyocin S3 were defective for pyoverdine-mediated iron uptake and failed to produce an 85-kDa iron-repressed outer membrane protein. We conclude that this protein is probably the type II ferripyoverdine receptor that is used by pyocin S3 to gain entry into the cell.