Risk factors of late rectal bleeding after carbon ion therapy for prostate cancer
Risk factors of late rectal bleeding after carbon ion therapy for prostate cancer
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DOI：
10.1016/j.ijrobp.2006.06.056
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发表时间：
2006-11-15
影响因子：
7
通讯作者：
Tsujii, Hirohiko
中科院分区：
文献类型：
--
作者：
Ishikawa, Hitoshi;Tsuji, Hiroshi;Tsujii, Hirohiko
本研究的目的是确定前列腺癌大分割碳离子放射治疗（C离子RT）后晚期胃肠道（GI）发病的危险因素。（方法和材料：在2000年4月至2003年11月期间，对175名前列腺癌患者进行了总剂量为66 GyE分20次的C离子RT的11期临床试验，并研究了172名存活超过18个月的患者中临床和剂量学参数与晚期GI毒性发生率的相关性。结果：在bar下虽然没有观察到3-4级直肠晚期发病，但分别有23例（13%）和4例（2%）患者发生1级和2级发病。剂量-体积直方图分析显示，直肠毒性患者接受50%处方剂量（V50）的直肠体积百分比显著高于无毒性患者（13.2 +/- 5.6%，有毒性; 11.4 +/- 4.0%，无毒性，p = 0.046）。多变量分析表明，使用抗凝治疗（p = 0.010）和直肠V50（p 0.012）是发生1-2级晚期GI毒性的显著风险因素。（结论：虽然低分割C离子放射治疗对晚期胃肠道并发症有良好的效果，但剂量学参数是C离子放射治疗和光子束放射治疗后直肠出血发生的一个非常重要的因素。我们的研究结果为医生应用带电粒子放射治疗前列腺癌提供了有用的信息。(c)2006年爱思唯尔公司
(Purpose:) under bar The aim of this study was to determine the risk factors for late gastrointestinal (GI) morbidity after hypofractionated carbon ion radiotherapy (C-ion RT) for prostate cancer.(Methods and Materials: ) under bar Between April 2000 and November 2003, a Phase 11 clinical trial of C-ion RT with a total dose of 66 GyE in 20 fractions was performed on 175 patients with prostate cancer, and the correlations of clinical and dosimetric parameters with the incidence of late GI toxicity in 172 patients who survived for more than 18 months were investigated.(Results:) under bar Although no Grade 3-4 late morbidities of the rectum were observed, Grade 1 and 2 morbidities developed in 23 (13%) and 4 (2%) patients, respectively. Dose-volume histogram analysis revealed that the percentage of rectal volume receiving 50% of the prescribed dose (V50) was significantly higher in patients with rectal toxicity than without toxicity (13.2 +/- 5.6% with toxicity; 11.4 +/- 4.0% without toxicity, p = 0.046). Multivariate analysis demonstrated that the use of anticoagulation therapy (p = 0.010) and rectal V50 (p 0.012) were significant risk factors for the occurrence of Grade 1-2 late GI toxicity.(Conclusions: ) under bar Although C-ion RT with hypofractionation yielded favorable results regarding late GI complication, dosimetric parameter was a very important factor in the occurrence of rectal bleeding after C-ion RT as well as photon beam RT. Our results provide useful information for physicians applying charged particle RT in the treatment of prostate cancer. (c) 2006 Elsevier Inc.