ALTERATIONS IN DNA METHYLATION IN HUMAN-COLON NEOPLASIA
ALTERATIONS IN DNA METHYLATION IN HUMAN-COLON NEOPLASIA
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DOI：
10.1002/ssu.2980030304
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发表时间：
1987-01-01
期刊：
影响因子：
--
通讯作者：
VOGELSTEIN, B
中科院分区：
文献类型：
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作者：
FEINBERG, AP;VOGELSTEIN, B
本文就DNA甲基化在结肠肿瘤中的研究进展作一综述。在研究的所有结肠癌中都发现了来自整个基因组的多种基因的低甲基化。这些变化先于恶性肿瘤，因为良性腺瘤也受到影响。
A review of studies on DNA methylation in colonic neoplasia is presented. Hypomethylation of a wide variety of genes from throughout the genome was seen in all colon cancers studied. These changes preceded malignancy because benign adenomas were also affected.