Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures
Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures
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DOI：
10.1039/b819905a
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发表时间：
2009-01-01
期刊：
影响因子：
3.4
通讯作者：
Spector, Jason A.
中科院分区：
文献类型：
--
作者：
Bellan, Leon M.;Singh, Sunil P.;Spector, Jason A.
使用牺牲糖结构，我们在聚合物基质中形成了 3D 流体血管网络。使用熔纺糖纤维（棉花糖）形成直径和密度与毛细血管相似的通道。为了与宏观流体系统连接，使用更大的牺牲糖结构来形成人工入口和出口。为了验证通道网络支持流动，我们使用视频荧光显微镜对水溶液中的 2 μm 荧光聚苯乙烯球和荧光标记的血液进行成像。这种制造工艺可应用于多种聚合物材料，并且快速、廉价且高度可扩展。
Using sacrificial sugar structures, we have formed a 3D fluidic vascular network in a polymeric matrix. Melt-spun sugar fibers (cotton candy) were used to form channels with diameters and densities similar to those of capillaries. To interface to macroscopic fluidic systems, larger sacrificial sugar structures were used to form an artificial inlet and outlet. To verify that the channel network supported flow, we used video fluorescence microscopy to image both 2 mu m fluorescent polystyrene spheres in an aqueous solution and fluorescently labeled blood. This fabrication process may be applied to a wide range of polymeric materials and is rapid, inexpensive, and highly scalable.