Possible functions of CD169-positive sinus macrophages in lymph nodes in anti-tumor immune responses.
Possible functions of CD169-positive sinus macrophages in lymph nodes in anti-tumor immune responses.
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DOI：
10.1111/cas.13137
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发表时间：
2017-03
期刊：
影响因子：
5.7
通讯作者：
Takeya M
中科院分区：
文献类型：
--
作者：
Komohara Y;Ohnishi K;Takeya M
淋巴结（LN）是一个重要的免疫系统，其中存在许多抗原呈递细胞，诱导对外来抗原的快速免疫反应。虽然淋巴结中存在大量巨噬细胞，但最近使用动物模型的研究表明，淋巴结窦巨噬细胞与诱导抗肿瘤免疫有关，在宿主对肿瘤细胞的免疫应答中发挥重要作用。在结直肠肿瘤、恶性黑色素瘤和子宫内膜肿瘤中，研究表明LN窦中CD169阳性巨噬细胞的高密度是临床预后较好的预测因素。LN窦内CD169阳性巨噬细胞的密度与肿瘤组织中浸润T细胞或NK细胞的密度呈正相关，提示CD169阳性巨噬细胞在肿瘤患者抗肿瘤免疫反应中的重要意义。此外，针对LN巨噬细胞的抗原递送也被认为是一种很有前途的疫苗接种方法。在本文中，我们总结了CD169阳性LN巨噬细胞在抗肿瘤免疫中的意义。
The lymph node (LN) is an important immune system in which a number of antigen‐presenting cells are present that induce rapid immune responses to foreign antigens. While a great number of macrophages exist in lymph nodes, recent studies using animal models have shown that lymph node sinus macrophages are associated with the induction of anti‐tumor immunity, playing a significant role in host immune responses against tumor cells. In colorectal tumor, malignant melanoma, and endometrial tumor, it was shown that a high density of CD169‐positive macrophages in the LN sinus was a predictive factor for better clinical prognosis. The observations that the density of CD169‐positive macrophages in the LN sinus was positively associated with the density of infiltrating T or NK cells in tumor tissues, indicates the significance of CD169‐positive macrophages in anti‐tumor immune reactions of tumor patients. Moreover, antigen delivery targeting LN macrophages is also considered to be promising approach for vaccination. In this article, we have summarized the significance of CD169‐positive LN macrophages in anti‐tumor immunity.