Comparison of the Ocular Hypotensive Effect of Brimonidine, Dorzolamide, Latanoprost, or Artificial Tears Added to Timolol in Glaucomatous Monkey Eyes
Comparison of the Ocular Hypotensive Effect of Brimonidine, Dorzolamide, Latanoprost, or Artificial Tears Added to Timolol in Glaucomatous Monkey Eyes
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DOI：
10.1097/00061198-200012000-00007
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发表时间：
2000-12
影响因子：
2
通讯作者：
Rong-Fang Wang;J. Serle;D. J. Gagliuso;S. Podos
中科院分区：
文献类型：
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作者：
Rong-Fang Wang;J. Serle;D. J. Gagliuso;S. Podos
目的：研究溴莫尼定、多佐胺、拉坦前列素或人工泪液与噻吗洛尔在激光诱导的猴单侧青光眼中的相加性眼水肿效应。方法：使用8只猴子，每只动物在研究期间以随机方式接受所有4种药物组合。每种组合之间的洗脱期至少为2周。在第1天（未治疗基线）、第2天（噻吗洛尔单独治疗）和第3 - 5天（两种药物联合治疗）的8：30 AM、11：00 AM、1：00 PM和3：30 PM测量眼内压（IOP）。在第1天下午3：45以及第2 - 5天上午8：45和下午3：45局部应用一滴0.5%噻吗洛尔。在第2天下午4：00以及第3 - 5天上午9：00和下午4：00加入一滴0.2%溴莫尼定或2%多佐胺或人工泪液，或在第3 - 5天上午9：00加入拉坦前列素。结果如下：与噻吗洛尔单药相比，第5天IOP的最大累加降低为4.8 ± 0.8 mm Hg（平均值±平均值的标准误），噻吗洛尔+溴莫尼定为5.6 ± 1.0 mm Hg，噻吗洛尔+多佐胺为4.3 ± 1.0 mm Hg，噻吗洛尔加人工泪液为2.0 ± 0.5 mm Hg（P 0.60）当在所有测量中比较噻吗洛尔+溴莫尼定和噻吗洛尔+多佐胺、噻吗洛尔+溴莫尼定和噻吗洛尔+拉坦前列素、噻吗洛尔+多佐胺和噻吗洛尔+拉坦前列素时，但在第5天0小时，噻吗洛尔联合多佐胺比噻吗洛尔联合拉坦前列素引起更大（P < 0.05）的IOP降低。结论：在噻吗洛尔基础上添加溴莫尼定、多佐胺或拉坦前列素，可导致昏迷猴眼IOP出现类似的额外降低。
Purpose: To investigate the additive ocular hypotensive effect of brimonidine, dorzolamide, latanoprost, or artificial tears to timolol in monkey eyes with laserinduced unilateral glaucoma. Methods: Eight monkeys were used and each animal received all four combinations of drugs in a randomized fashion during the study. The washout period between each combination was at least 2 weeks. Intraocular pressure (IOP) was measured at 8:30 AM, 11:00 AM, 1:00 PM, and 3:30 PM on day 1 (untreated baseline), day 2 (timolol treatment alone), and days 3 through 5 (combination therapy with two drugs). One drop of 0.5% timolol was topically applied at 3:45 PM on day 1 and at 8:45 AM and 3:45 PM on days 2 through 5. One drop of 0.2% brimonidine or 2% dorzolamide or artificial tears was added on day 2 at 4:00 PM and at 9:00 AM and 4:00 PM on days 3 through 5, or latanoprost was added at 9:00 AM on days 3 through 5. Results: Compared with timolol alone, the maximal additive reduction in IOP which occurred on day 5 was 4.8 ± 0.8 mm Hg (mean ± standard error of the mean) with timolol plus brimonidine, 5.6 ± 1.0 mm Hg with timolol plus dorzolamide, 4.3 ± 1.0 mm Hg with timolol plus latanoprost, and 2.0 ± 0.5 mm Hg with timolol plus artificial tears (P 0.60) when comparing timolol plus brimonidine and timolol plus dorzolamide, timolol plus brimonidine and timolol plus latanoprost, timolol plus dorzolamide and timolol plus latanoprost at all measurements, but timolol plus dorzolamide caused a greater (P < 0.05) reduction of IOP than did timolol plus latanoprost at 0 hours on day 5. Conclusions: The addition of brimonidine, dorzolamide, or latanoprost to timolol caused similar additional reductions of IOP in glaucomatous monkey eyes.