One-pot method to prepare a theranostic nanosystem with magnetic resonance imaging function and anticancer activity through multiple mechanisms
One-pot method to prepare a theranostic nanosystem with magnetic resonance imaging function and anticancer activity through multiple mechanisms
复制标题
一锅法通过多种机制制备具有磁共振成像功能和抗癌活性的治疗诊断纳米系统
DOI：
10.1039/c7dt00489c
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发表时间：
2017
影响因子：
4
通讯作者：
Shen Jian
中科院分区：
文献类型：
--
作者：
Chen Enyi;Chen Xin;Yuan Xiuxue;Wei Shaohua;Zhou Lin;Zhou Jiahong;Shen Jian
基于Gd 3+与金丝桃素光敏剂（PS）之间的螯合作用和它们的受控原位水解沉淀，开发了一种简便且稳健的一锅法制备治疗诊断纳米平台。在该策略中，PS药物和Gd 3+直接用作构建块来构建治疗诊断纳米颗粒，从而大大提高了活性物质的负载效率并确保其治疗诊断效果。所得到的纳米颗粒具有用于核磁共振（NMR）成像和通过三磷酸腺苷（ATP）剥夺和重原子效应（HAE）-改进的光动力疗法（PDT）机制的抗癌活性的多功能能力。
A facile and robust one-pot approach to prepare a theranostic nanoplatform, based on chelation between Gd3+ and hypericin photosensitizer (PS) and their controlled in situ hydrolysis precipitation, was developed. In this strategy, PS drugs and Gd3+ were directly used as building blocks to construct theranostic nanoparticles, resulting in a greatly increased active substance-loading efficiency and ensuring their theranostic effect. The resulting nanoparticles have multifunction capabilities for nuclear magnetic resonance (NMR) imaging and anticancer activity through adenosine triphosphate (ATP) deprivation and heavy atom effect (HAE)-improved photodynamic therapy (PDT) mechanisms.