Behavioral Science and the Study of Gene-Nutrition and Gene-Physical Activity Interactions in Obesity Research
Behavioral Science and the Study of Gene-Nutrition and Gene-Physical Activity Interactions in Obesity Research
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DOI：
10.1038/oby.2008.524
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发表时间：
2008-12-01
期刊：
影响因子：
6.9
通讯作者：
Faith, Myles S.
中科院分区：
文献类型：
--
作者：
Faith, Myles S.
本报告总结了行为科学的新机遇，以帮助推进基因-环境和基因-行为相互作用领域，基于国家癌症研究所（NCI）研讨会的演讲，“肥胖病因学中的基因营养和基因-身体活动相互作用。重点介绍了三个机会：（i）在实验中设计有效的行为“挑战”，（ii）确定遗传学研究的可行行为表型，以及（iii）确定环境或环境暴露的具体措施。强调了其他要点，包括需要纳入神经影像学研究中关于饮食和体力活动的动机和驱动力的新发现。行为科学理论和方法的进步可以在促进对肥胖发病中基因-大脑-行为关系的理解方面发挥重要作用。
This report summarizes emerging opportunities for behavioral science to help advance the field of gene-environment and gene-behavior interactions, based on presentations at The National Cancer Institute (NCI) Workshop, "Gene Nutrition and Gene-Physical Activity Interactions in the Etiology of Obesity." Three opportunities are highlighted: (i) designing potent behavioral "challenges" in experiments, (ii) determining viable behavioral phenotypes for genetics studies, and (iii) identifying specific measures of the environment or environmental exposures. Additional points are underscored, including the need to incorporate novel findings from neuroimaging studies regarding motivation and drive for eating and physical activity. Advances in behavioral science theory and methods can play an important role in advancing understanding of gene-brain-behavior relationships in obesity onset.