A mixed exercise training programme is feasible and safe and may improve quality of life and muscle strength in multiple myeloma survivors
A mixed exercise training programme is feasible and safe and may improve quality of life and muscle strength in multiple myeloma survivors
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DOI：
10.1186/1471-2407-13-31
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发表时间：
2013-01-24
期刊：
影响因子：
3.8
通讯作者：
Yong, Kwee L.
中科院分区：
文献类型：
--
作者：
Groeneveldt, Lara;Mein, Gill;Yong, Kwee L.
背景：运动计划对癌症患者有益，但对多发性骨髓瘤（MM）患者的证据有限，多发性骨髓瘤是一种以溶解性骨病为特征的癌症，导致骨折和骨痛等高水平的骨骼发病率。方法：我们进行了一项单臂2期研究，以评估运动计划（EP）作为治疗MM患者康复的可行性、对生活质量和生理参数的影响。患者被给予个性化的方案，包括拉伸，有氧和阻力运动，在监督下进行3个月，然后在家再进行3个月。结果：研究吸收率高，75例患者中有60例（80%）同意研究。筛选失败（11例，由于骨折风险和疾病复发）和患者退出（12例）导致最终37例患者参加了该计划。这37名患者在有监督的课程中表现出很高的出勤率（87%），并且在家庭锻炼中表现出很高的依从性（73%）。EP后患者的生活质量得到改善，FACT-G和疲劳评分较基线有所改善(p
Background: Exercise programmes are beneficial for cancer patients however evidence is limited in patients with multiple myeloma (MM), a cancer that is characterised by osteolytic bone disease, giving rise to high levels of bone morbidity including fractures and bone pain.Methods: We conducted a single arm phase 2 study of an exercise programme (EP) as rehabilitation for treated MM patients, to evaluate feasibility, effects on QOL and physiological parameters. Patients were given individualised programmes, comprising stretching, aerobic and resistance exercises, carried out under supervision for 3 months then at home for a further 3 months.Results: Study uptake was high, 60 of 75 (80%) patients approached consented to the study. Screen failures (11, due to fracture risk and disease relapse) and patient withdrawals (12) resulted in a final 37 patients enrolling on the programme. These 37 patients demonstrated high attendance rates in the supervised classes (87%), and high levels of adherence in home exercising (73%). Patients reported better QOL following the EP, with improvement in FACT-G and Fatigue scores over time from baseline (p