Myeloid Derived Suppressor Cells and Their Role in Diseases
Myeloid Derived Suppressor Cells and Their Role in Diseases
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DOI：
10.2174/0929867311320110006
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发表时间：
2013-04-01
影响因子：
4.1
通讯作者：
Plebanski, M.
中科院分区：
文献类型：
--
作者：
Kong, Y. Y.;Fuchsberger, M.;Plebanski, M.
髓系抑制细胞(MDSCs)是髓系祖细胞的异质性群体，在肿瘤发展和慢性炎症中发挥重要作用。MDSCs抑制功能的重要性最初是由涉及癌症患者和荷瘤小鼠的研究提出的。此外，最近的研究表明，MDSCs还可以参与许多其他病理情况。除了其他类型的免疫抑制细胞所利用的免疫反应外，MDSCs还有独特的方式来消除免疫反应，例如通过诱导精氨酸酶-1，从而上调活性氧物种(ROS)的产生。由于它们的异质性，它们还可以表达各种谱系标记，这些标记与其他髓系细胞类型如Gr1、CD11b、MHCIIlo、Ly6C和Ly6G重叠，因此仅凭表面表型很难识别它们。鼠和人的MDSCs之间的差异进一步使这些难以捉摸的细胞群的鉴定变得复杂。在这篇综述中，我们将总结最近关于诱导和研究不同MDSC亚群的方法的最新进展，包括新提出的表面表型，以及对它们在小鼠和人类中的功能特征的洞察力。此外，令人兴奋的新发现表明它们涉及许多不同的病理环境，如败血症、自身免疫和利什曼病，将被讨论。
Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid progenitors that can play a major role in tumour development and chronic inflammation. The importance of the suppressive function of MDSCs was first suggested by studies involving cancer patients and cancer-bearing mice. In addition, recent studies have demonstrated that MDSCs can also be involved in many other pathological conditions. MDSCs have unique ways of abrogating an immune response in addition to those utilised by other immune-suppressive cell types, for example via the induction of arginase-1 and consequent upregulation in reactive oxygen species (ROS) production. Due to their heterogeneity, they further can express a variety of lineage markers, which overlap with other myeloid cell types such as Gr1, CD11b, MHCIIlo, Ly6C and Ly6G, making it difficult to identify them by surface phenotype alone. The disparity between mouse and human MDSCs further complicates the identification of these elusive cell populations. In this review, we will summarise the recent updates on the methods for eliciting and studying different MDSC subsets, including newly proposed surface phenotypes, as well as insights into how their function is being characterised in both mice and humans. In addition, exciting new discoveries suggesting their involvement across a number of different pathological settings, such as sepsis, autoimmunity and Leishmaniasis, will be discussed.