Analysis of antibodies to surface epitopes of contactin-2 in multiple sclerosis.
Analysis of antibodies to surface epitopes of contactin-2 in multiple sclerosis.
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DOI：
10.1016/j.jneuroim.2011.12.023
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发表时间：
2012-03
影响因子：
3.3
通讯作者：
Saiz A
中科院分区：
文献类型：
--
作者：
Boronat A;Sepúlveda M;Llufriu S;Sabater L;Blanco Y;Gabilondo I;Solà N;Villoslada P;Dalmau J;Graus F;Saiz A
Contactin-2是近年发现的多发性硬化症(MS)患者T细胞和自身抗体靶向的自身抗原。在这里，我们分析了105名MS患者和至少5年的随访(19例临床孤立综合征，51例复发缓解，20例继发性进展，15例原发进展)患者血清中抗Conactin-2(Conactin-2-ab)抗体的频率。4例(7.8%)复发缓解期患者检测到Contactin-2-ab。临床和磁共振成像特征与其他复发缓解患者没有显著差异。总而言之，在少数MS患者中发现了Conactin-2-ab，但它们的存在与特定的临床-放射学特征无关。
Contactin-2 was recently identified as an autoantigen targeted by T-cells and autoantibodies in multiple sclerosis (MS). Here we analyzed the frequency of antibodies to contactin-2 (contactin-2-ab) by a cell-based assay in the serum from 105 MS patients and at least 5 years of follow-up (19 clinically isolated syndromes, 51 relapsing–remitting, 20 secondary-progressive, and 15 primary-progressive). Contactin-2-ab were detected in 4 (7.8%) relapsing–remitting patients. Clinical and magnetic resonance imaging characteristics were not significantly different from the rest of relapsing–remitting patients. In conclusion, contactin-2-ab are identified in a minority of MS patients but their presence is not associated with a particular clinical-radiological profile.